In a genetic female, bipotential
gonads develop as ovaries; other undifferentiated structures develop as uterus, oviducts, vagina, clitoris, and labia.
Induction of sex change in teleost fish is possible because germ cells are bipotential
and their sensitivity to exogenous hormones allow disruption of the natural biochemical processes that govern sex differentiation, overriding normal developmental patterns even after gonadal differentiation has taken place (Devlin & Nagahama, 2002; Strussmann & Nakamura, 2002).
The second phase is transference of the chromosomal sex into gonadal sex, which involves differentiation of the bipotential
gonad into a testis or ovary.
method put forward by De Saxce and Feng  achieves this goal.
roles of ceramide in the growth of hippocampal neurons: Promotion of cell survival and dendritic outgrowth in doseand developmental stage-dependent manners," Journal of Neuroscience Research, vol.
Gerber, "Identification of bipotential
progenitor cells in human liver development," Hepatology, vol.
You et al., "Reprogramming fibroblasts into bipotential
hepatic stem cells by defined factors," Cell Stem Cell, vol.
A 46,XY chromosome component normally drives the bipotential
gonads to develop into testes, while 46,XX affords ovarian development.
According to the sex chromosomes of the individual and the effect of transcriptional factors, testis or ovary develop from the embryonic bipotential
Kosan et al., "Growth factor independence 1 (Gfi1) regulates cell-fate decision of a bipotential
granulocytic-monocytic precursor defined by expression of Gfi1 and CD48," American Journal of Blood Research, vol.
Early in gestation, undifferentiated gonads are believed to be bipotential
for either gender within the first 3-5 weeks of pregnancy.
Schug et al., "Prospective isolation of a bipotential
clonogenic liver progenitor cell in adult mice," Genes & Development, vol.