The article, entitled "Programming Fibroblasts into Bipotential
Hepatic Stem Cells by Defined Factors" is available in the July online Cell Stem Cell journal.
Chatterjee, "Simulated Microgravity Promoted Differentiation of Bipotential
Murine Oval Liver Stem Cells by Modulating BMP4/Notch1 Signaling".
only in the 7th week does the structure called the bipotential
gonad begin to take on the distinctive appearance of a testis or an ovary.
10) In normal lymphoid development, the emergence of early T-lineage precursors from bipotential
progenitor cells involves suppression of these B-lineage-specific transcription factors by Notchl.
Two to 3 weeks before exposures, rats were surgically implanted with bipotential
PhysioTel transmitters (TA11CTA-F40; Data Sciences International, St.
Are we born truly malleable, fully bipotential
, and it is experience and social context that give our gender identity form?
Solving Frictional Contact Problems within the Bipotential
Sex differentiation is the process by which gonads develop into either testes or ovaries from an undifferentiated or bipotential
gonad (Hayes 1998).
The [Beta]III-positive phenotypes in SEGAs may thus represent (1) divergent neuronal phenotypes corresponding to transformed bipotential
precursor cells of the subependymal matrix displaying either neuronal ([Beta]III-positive) or glial (GFAP-positive) differentiation, (2) entrapped remnants of dysgenetic, incompletely differentiated neuronal cells resulting from deranged ontogeny and disrupted migration of neuronal precursors of the subependymal germinal matrix, or (3) transformed glial cells in which there is anomalous induction of [Beta]III that is not associated with cell proliferation (ie, in the unique setting of this dysgenetic tumor).
The research, which appears today online (ahead of print) in the journal Nature Methods, by Advanced Cell Technology (ACT) and its collaborators, describes an efficient method for generating large numbers of bipotential
progenitors--known as hemangioblasts--from hES cells that are capable of differentiating into blood vessels, as well as into all blood and immune cell lineages.
These results suggest that OP advanced the stage at which the bipotential
gonad differentiates into a morphologically distinct ovary or testis.
17] Leukemias postulated to arise from bipotential
precursor cells (myeloid/NK cell acute leukemia) and a related entity with blastic cytologic features (myeloid/NK precursor acute leukemia) have also been reported.