Early in gestation, undifferentiated gonads are believed to be bipotential
for either gender within the first 3-5 weeks of pregnancy.
Hepatoblasts are bipotential
liver progenitor cells that can differentiate into either hepatocytes, cells that comprises the majority of liver tissue, or cholangiocytes, epithelial cells of the bile duct.
They discuss such topics as registering, evaluating, authorizing, and restricting (REACH) environmental chemicals, early embryo development and bipotential
gonad formation, assessing the reproductive health of men with occupational exposures, molecular structural characteristics that influence partitioning of xenobiotics into human breast milk, and adverse outcome pathways for developmental toxicity.
Granneman, "In vivo identification of bipotential
adipocyte progenitors recruited by [beta]3-adrenoceptor activation and high-fat feeding," Cell Metabolism, vol.
With the understanding that PPAR controls fat (adipogenesis) and bone (osteogenesis) development, Schlezinger and her team reasoned that inappropriate activation of these receptors by organotins might skew differentiation of a bipotential
mesenchymal stem cell toward the adipocyte lineage and away from the osteogenic lineage (Yanik et al.
3,4) GFAP has been detected by some authors in CN, (2) which may indicate that the cell of origin may be a bipotential
cell of germinal matrix origin.
The critical factor that signals the bipotential
gonad to develop into a testis is a gene called the H-Y antigen, located on the short arm of chromosome Y.
The article, entitled "Programming Fibroblasts into Bipotential
Hepatic Stem Cells by Defined Factors" is available in the July online Cell Stem Cell journal.
Anderson DJ, Axel R (1986) A bipotential
neuroendocrine precursor whose choice of cell fate is determined by NGF and glucocorticoids.
Different types of fetal liver (stem) cells during development were identified, and their advantageous growth potential and bipotential
differentiation capacity towards liver or biliary cells has been shown (24-26).
Chatterjee, "Simulated Microgravity Promoted Differentiation of Bipotential
Murine Oval Liver Stem Cells by Modulating BMP4/Notch1 Signaling".
Table 1: Differential potential ranges of Different Stem Cells Differentiation Number of cell Example of stem types cell Totipotent All Zygote, blastomere Pleuripotent All except cells Embryonic Stem of the embryonic cells membranes Multipotent Many Hematopoietic cells Oligopotent Few Myeloid precursor Quadripotent 4 Mesenchymal progenitor cell Tripotent 3 Glial-restricted precursor Bipotent 2 Bipotential
precursor from murine fetal liver Unipotent 1 Mast cell precursor Nullipotent None Terminally differentiated cell e.