Recommend bismuth subsalicylate
chemoprophylaxis for travelers at high risk for TD who are willing to comply with the regimen and want to avoid antibiotic prophylaxis.
Subjects who met the study entry criteria were randomized in a 1:1 ratio to receive 14 days of treatment with either bismuth subsalicylate
(Pepto-Bismol, Proctor & Gamble, Cincinnati, OH) 2 tablets, metronidazole 250 mg tablet, tetracycline 500 mg tablet (BMT), each administered 4 times daily (at 8:00 AM, 12:00 PM, 4:00 PM, and 8:00 PM) plus cimetidine 400-mg tablet administered twice daily (at 8:00 AM and 8:00 PM) or lansoprazole 30-mg tablet, amoxicillin 1000-mg tablet, and clarithromycin 500-mg tablet (LAC), each administered twice daily at 8:00 AM and 8:00 PM.
As a result, strict adherence to preventive measures is encouraged, and bismuth subsalicylate
should be used as an adjunct if prophylaxis is needed.
Flagyl[R]) with bismuth subsalicylate
preparation (1 oz every 30 minutes for eight doses) decreased the rate of stooling by one-half in a study of travelers with diarrhea when compared with a placebo group.
Trimethoprim 200mg + Sulphadiazine 1000mg Bolus Neomycin Sulphate 1000mg + Bismuth Subsalicylate
, which you probably know as Pepto-Bismol, can also work.
Steroids may be used to reduce bowel inflammation; antidiarrheal drugs such as bismuth subsalicylate
(Pepto-Bismol), diphenoxylate and atropine (Lomotil), and loperamide (Imodium) offer short-term relief.
, such as Pepto-Bistool and Kaopectate, should not be used in pregnancy or lactation since metabolism releases salicylate.
Miscellaneous Bismuth subsalicylate
(Pepto Inhibit pepsin, form Bismol), misoprostol barrier to protect (Cytotec), sucralfate stomach lining.
, such as Pepto-Bismol and Kaopectate, should not be used in pregnancy or lactation since metabolism releases salicylate.
Two well-designed South American studies (1,2) both found that bismuth subsalicylate
(Pepto-Bismol) at a dose of 1.