Wortinger et al., "LY2875358, a neutralizing and internalizing anti-MET bivalent antibody
, inhibits HGF-dependent and HGF-independent MET activation and tumor growth," Clinical Cancer Research, vol.
Similar results speaking in favor of a smaller bivalent antibody
fragment were obtained when a Fab, a bivalent F[(ab').sub.2], and a full-length version of mAb U36 were compared side by side in vitro and in mice carrying CD44v6-expressing xenografts .
[beta]-2-Glycoprotein I dependent lupus anticoagulants form stable bivalent antibody
[beta]-2-glycoprotein I complexes on phospholipid surfaces.
Craig (11) proposed previously that the immunospecific binding of antibody fragments to analyte-modified particles changes the colloidal properties of the latex particles, thus triggering agglutination without the need for bridging of particles by the bivalent antibody
. Strong evidence for the validity of this mechanism was reported by Thompson et al.