bivalent antibody


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bivalent antibody

[bī′vāl·ənt ′ant·i‚bäd·ē]
(immunology)
An antibody possessing two antibody combining sites.
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References in periodicals archive ?
Wortinger et al., "LY2875358, a neutralizing and internalizing anti-MET bivalent antibody, inhibits HGF-dependent and HGF-independent MET activation and tumor growth," Clinical Cancer Research, vol.
Similar results speaking in favor of a smaller bivalent antibody fragment were obtained when a Fab, a bivalent F[(ab').sub.2], and a full-length version of mAb U36 were compared side by side in vitro and in mice carrying CD44v6-expressing xenografts [63].
[beta]-2-Glycoprotein I dependent lupus anticoagulants form stable bivalent antibody [beta]-2-glycoprotein I complexes on phospholipid surfaces.
Craig (11) proposed previously that the immunospecific binding of antibody fragments to analyte-modified particles changes the colloidal properties of the latex particles, thus triggering agglutination without the need for bridging of particles by the bivalent antibody. Strong evidence for the validity of this mechanism was reported by Thompson et al.