Serum levels of mature microRNAs in DICER1-mutated pleuropulmonary blastoma
. Oncogenesis 2014;3:e87.
At imaging, round pneumonias may appear similar to a parenchymal bronchogenic cysts, pleuropulmonary blastoma
or metastatic disease.
, rabdomyosarcoma, bronchogenic carcinoma and various sarcomas were reported in the literature which got derived from CPAMs (8-11).
This tumor has been categorized as a sarcomatoid carcinoma, along with other subtypes, including pleomorphic carcinoma, spindle cell carcinoma, carcinosarcoma, and pulmonary blastoma
. WHO  and IASLC/ATS/ERS  guidelines include the pathological terminology and criteria that should be applied in small biopsy specimens, as most patients with inoperable tumors are diagnosed by pathologic examination of small samples, and many of these lung tumors are pathologically heterogeneous.
In rare cases, reports of malignant transformation, including pulmonary blastoma
, rhabdomyosarcoma, and bronchoalveolar carcinoma, have been found in the resected bronchogenic cyst in adults (0.7%) and children .
DICER1 syndrome is a familial tumour susceptibility syndrome associated with pleuropulmonary blastoma
; ovarian sex cord-stromal tumours; cystic nephroma; thyroid gland neoplasia; and other rare benign and malignant tumours.
NCMH has been associated with development of pleuropulmonary blastoma
(PPB) during infancy.
One patient with concurrently diagnosed pleuropulmonary blastoma
and embryonal rhabdomyosarcoma of the cervix had a DICER1 germline mutation .
Later chest CT without contrast revealed 10 x 14 x 16 cm mass in the right lung without hilar lymphadenopathy, small pericardial effusion, bilateral pleural effusions, and compressive atelectasis of the right lung (Figure 2) and possible differentials were pleural fibroma, sarcoma, pulmonary pleural blastoma
, and primary pulmonary lymphoma (no palpable lymph nodes).
A 2004 classification by the World Health Organization (WHO) grouped sarcomatoid carcinomas into several categories, including pleomorphic carcinoma, spindle cell carcinoma, giant cell carcinoma, carcinosarcoma, and pulmonary blastoma
The potential anticancer and antiangiogenesis properties of AL extract and its major constituents have been demonstrated in various cancer, for examples, murine blastoma
cells Hela (human cervical cells), SGC-7901 (human gastric cancer cells), BEL-7402 (human liver cancer cells), H33, S180, HL-60 leukemic cells, and gastric cancer [57-61].
Los tumores pulmonares incluyen tanto las lesiones malignas como los adenomas bronquiales, los carcinoides, los carcinomas mucoepidermoides, el blastoma
pleuropulmonar, los carcinomas adenoides quisticos y los tumores benignos .