Josef Penninger and his colleagues have developed a method to grow three-dimensional human blood vessels
(organoids) in a petri dish.
The researchers then searched for chemical compounds that could block thickening of the blood vessel
However, as we age, the blood vessels
don't fit as tightly together, which may allow amyloid beta and tau to enter the brain.
The findings show that CD157-positive vascular endothelial stem cells give rise to a hierarchy of cell types that can repair vascular injury and maintain the normal blood vessel
"Today we actually propose that blood vessels
can form tumors and then the whole picture becomes a cycle," said Dr.
However, the catheter inserted to take the IVUS image heavily deforms the blood vessel
, as shown in Figure 1.
BALTIMORE, M.D.., December 20, 2012 -- Growing new blood vessels
in the lab is a tough challenge, but an engineering team has solved a major stumbling block: how to prod stem cells to become two different types of tissue that are needed to build tiny networks of veins and arteries.
Lead researcher Professor Wilfred Jefferies, from the University of British Columbia in Canada, said: "When the blood vessels
grow, the cells of the vessel walls propagate by dividing.
"The idea of promoting the supporting cellular actors rather than the leading actors opens new ways of thinking about blood vessel
regeneration and new possibilities for treating patients with vascular disease."
On the other hand, extra blood vessel
development may be needed in patients who suffered strokes, heart attacks or diabetes.
These results not only serve to solve a profound scientific mystery, but hold great promise for preventing and curing blinding eye disease and illnesses such as cancer, in which blood vessels
grow abnormally and uncontrollably, since this phenomenon, normally present in the cornea, can be used therapeutically in other tissues.
Chemotactant proteins are expressed on the endothelial cell of the dilated blood vessels
that serve as recruitment factors for lymphocytes.