failure

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Related to bone marrow failure: aplastic anemia

failure

[′fāl·yər]
(engineering)
A permanent change in the volume of a powder or the stresses within it.
(mechanics)
Condition caused by collapse, break, or bending, so that a structure or structural element can no longer fulfill its purpose.

Failure

A condition when a structure or material ceases to fulfill its required purpose. The failure of a structural member may be caused by elastic deformation, fracture, or excessive deflection. The nonstructural failure of a material may be due to weathering, abrasion, or chemical action.

Failure

 

Failure is a consequence of a change in the parameters of a device or of its parts, resulting from internal physicochemical processes and the effect of the environment.

A distinction is made between sudden failure and gradual failure. Sudden failure is characterized by an abrupt change in the values of one or more fundamental parameters of a device (for example, the burnout of the incandescent filament in an electric lamp); in gradual failure, there is a slow change in the values of one or more fundamental parameters of a device (for example, the decrease of engine power to a level below the rated power). The criteria for failure are established in the technical specifications for a particular item.

As a result of failure, a device may stop operating completely, or its operating efficiency may fall below the permissible level. Failure of an element in a device that is not caused by damage to other elements is called independent failure; failure resulting from damage or the complete failure of other elements is called dependent failure.

V. N. FOMIN

What does it mean when you dream about a failure?

Dreaming about failing, in school or in some task, may simply be an expression of anxiety (i.e., it is not a sign predicting that someone will fail). People who regularly dream of failing are often perfectionists.

failure

In structural engineering, that condition of a structural element (or its material components) which renders it incapable of continuing the load-carrying function for which it was designed; may be caused by fracture or by excessive and permanent plastic deformation.

Failure

Army Bomb Plot
attempted assassination of Hitler; his miraculous escape brought dreadful retaliation (1944). [Ger. Hist.: Van Doren, 500]
Brown, Charlie
comic strip character for whom losing is a way of life. [Comics: “Peanuts” in Horn, 542–543]
Bunion Derby
financially disastrous cross-country marathon. [Am. Hist.: Sann, 48–56]
Carker, John
broken-spirited man occupying subordinate position. [Br. Lit.: Dombey and Son]
Edsel
much bruited automobile fails on market (1950s). [Am. Hist.: Flexner, 78]
English, Julian
contentious and unloved salesman; commits suicide in despair. [Am. Lit.: Appointment in Samarra]
Gunpowder Plot
attempt to blow up the Parliament building; led to the execution of its leader, Guy Fawkes (1605). [Brit. Hist.: EB, IV: 70–71]
Little Tramp Chaplin’s
much-loved, much-imitated hapless, “I’m a failure” persona. [Am. Cinema: Griffith, 79]
Loman, Willy
traveling salesman who gradually comes to realize that his life has been a complete failure; commits suicide. [Am. Lit.: The Death of a Salesman, Payton, 397]
Mighty Casey
ignominiously strikes out in the clutch. [Am. Lit.: “Casey at the Bat” in Turkin, 642]
Reardon, Edwin
very promising writer who, after unsuccessful publication, returns to clerical job. [Br. Lit.: New Grub Street, Magill I, 647–649]
Skid Row
district of down-and-outs and bums. [Am. Usage: Brewer Dictionary, 1008]
WIN buttons
President Ford’s scheme to reduce inflation: for the American public to wear shields stating “WIN.” (Whip Inflation Now). [Am. Hist.: Misc.]
World League
“ingenious” creation of a third professional league that never materialized. [Am. Sports: Misc.]
Yank
steamship stoker vainly tries to climb the social ladder, then fails in attempt to avenge himself on society. [Am. Drama: O’Neill The Hairy Ape in Sobel, 339]

failure

The inability of a system or system component to perform a required function within specified limits. A failure may be produced when a fault is encountered.
References in periodicals archive ?
Bone marrow failure and the new telomere diseases: practice and research.
Jacobs, "Bone marrow failure: pathophysiology and management," Disease-a-Month, vol.
One case was a familial bone marrow failure syndrome which was later diagnosed as Fanconi anemia by chromosomal breakage analysis.
Acquired AA is prototypical of human bone marrow failure. The incidence in Western countries is two cases per million per year while in Asia this number is approximately two- to threefold higher.
Acute leukemia and bone marrow failure are the most common causes yet megaloblastic anemia and infections are the treatable and reversible causes of pancytopenia.
The book is divided into thirteen sections: I and II cover inherited and acquired red cell disorders; III inherited white cell and platelet disorders; IV infectious disorders, V hemostatic disorders; VI bone marrow failure syndromes; VII reactive lymphadenopathies; VIII reactive histiocyticlymphoproliferative disorders; XI myeloid neoplasms; XII histiocytoic and dendritic cell neoplasms; and XIII is thymoma and thymic carcinoma.Hematopathology is an invaluable resource for hematopathologists, general pathologists, and students.
(1-3) DC is a clinically heterogeneous inherited bone marrow failure syndrome (IBMFS), that epitomizes the clinical consequences of very short telomeres and mutations in telomere biology.
Now, a team of researchers led by biologists at the California Institute of Technology has found in mouse models that the molecule microRNA-146a (miR-146a) acts as a critical regulator and protector of blood-forming stem cells (called hematopoietic stem cells, or HSCs) during chronic inflammation, suggesting that a deficiency of miR-146a may be one important cause of blood cancers and bone marrow failure.
"In addition to creating new capabilities and in vitro assays for drug rescue and predictive toxicology, these advancements open the door to development of new treatments for bone marrow failure, anemia, viral diseases and other conditions that compromise the immune system," said CEO Shawn Singh.
The authors present a classic case of dyskeratosis congenita (DC) and nicely summarize the variability in clinical and diagnostic findings in patients with inherited bone marrow failure syndromes (IBMFSs).
Though Alise is still battling her condition, the bone marrow transplant will protect her from bone marrow failure and from the chance of an onset of leukemia that often accompanies Fanconi anemia.
Specific disorders eligible for HPC-C treatment include patients with hematologic malignancies, primary immunodeficiency diseases, bone marrow failure, and beta-thalassemia.

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