failure

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Related to bone marrow failure: aplastic anemia

failure

[′fāl·yər]
(engineering)
A permanent change in the volume of a powder or the stresses within it.
(mechanics)
Condition caused by collapse, break, or bending, so that a structure or structural element can no longer fulfill its purpose.

Failure

A condition when a structure or material ceases to fulfill its required purpose. The failure of a structural member may be caused by elastic deformation, fracture, or excessive deflection. The nonstructural failure of a material may be due to weathering, abrasion, or chemical action.

Failure

 

Failure is a consequence of a change in the parameters of a device or of its parts, resulting from internal physicochemical processes and the effect of the environment.

A distinction is made between sudden failure and gradual failure. Sudden failure is characterized by an abrupt change in the values of one or more fundamental parameters of a device (for example, the burnout of the incandescent filament in an electric lamp); in gradual failure, there is a slow change in the values of one or more fundamental parameters of a device (for example, the decrease of engine power to a level below the rated power). The criteria for failure are established in the technical specifications for a particular item.

As a result of failure, a device may stop operating completely, or its operating efficiency may fall below the permissible level. Failure of an element in a device that is not caused by damage to other elements is called independent failure; failure resulting from damage or the complete failure of other elements is called dependent failure.

V. N. FOMIN

What does it mean when you dream about a failure?

Dreaming about failing, in school or in some task, may simply be an expression of anxiety (i.e., it is not a sign predicting that someone will fail). People who regularly dream of failing are often perfectionists.

failure

In structural engineering, that condition of a structural element (or its material components) which renders it incapable of continuing the load-carrying function for which it was designed; may be caused by fracture or by excessive and permanent plastic deformation.

Failure

Army Bomb Plot
attempted assassination of Hitler; his miraculous escape brought dreadful retaliation (1944). [Ger. Hist.: Van Doren, 500]
Brown, Charlie
comic strip character for whom losing is a way of life. [Comics: “Peanuts” in Horn, 542–543]
Bunion Derby
financially disastrous cross-country marathon. [Am. Hist.: Sann, 48–56]
Carker, John
broken-spirited man occupying subordinate position. [Br. Lit.: Dombey and Son]
Edsel
much bruited automobile fails on market (1950s). [Am. Hist.: Flexner, 78]
English, Julian
contentious and unloved salesman; commits suicide in despair. [Am. Lit.: Appointment in Samarra]
Gunpowder Plot
attempt to blow up the Parliament building; led to the execution of its leader, Guy Fawkes (1605). [Brit. Hist.: EB, IV: 70–71]
Little Tramp Chaplin’s
much-loved, much-imitated hapless, “I’m a failure” persona. [Am. Cinema: Griffith, 79]
Loman, Willy
traveling salesman who gradually comes to realize that his life has been a complete failure; commits suicide. [Am. Lit.: The Death of a Salesman, Payton, 397]
Mighty Casey
ignominiously strikes out in the clutch. [Am. Lit.: “Casey at the Bat” in Turkin, 642]
Reardon, Edwin
very promising writer who, after unsuccessful publication, returns to clerical job. [Br. Lit.: New Grub Street, Magill I, 647–649]
Skid Row
district of down-and-outs and bums. [Am. Usage: Brewer Dictionary, 1008]
WIN buttons
President Ford’s scheme to reduce inflation: for the American public to wear shields stating “WIN.” (Whip Inflation Now). [Am. Hist.: Misc.]
World League
“ingenious” creation of a third professional league that never materialized. [Am. Sports: Misc.]
Yank
steamship stoker vainly tries to climb the social ladder, then fails in attempt to avenge himself on society. [Am. Drama: O’Neill The Hairy Ape in Sobel, 339]

failure

The inability of a system or system component to perform a required function within specified limits. A failure may be produced when a fault is encountered.
References in periodicals archive ?
TERC and TERT gene mutations in patients with bone marrow failure and significance of telomere length measurements.
Both patients were diagnosed as having severe bone marrow failure after HLH that was similar to severe AA.
The first successful cord blood transplant occurred in 1988 in a six-year-old boy with bone marrow failure.
Fanconi anemia (FA), named for Swiss pediatrician Guidio Fanconi, is one of the inherited anemias that leads to bone marrow failure (aplastic anemia) and development of leukemia.
Clinical significance of a minor population of paroxysmal nocturnal hemoglobinuria-type cells in bone marrow failure syndrome.
Antibodies drawn from the animals' blood are giving 14-year-old aplastic anaemia patient Cara Heaney a chance of survival as she fights bone marrow failure.
Peter has Fanconi anemia, which leads to bone marrow failure.
The finding of hypercellularity in biopsied bone marrow helps to rule out bone marrow failure.
These include most prominently, bone marrow failure and its consequences of anemia, hemorrhage, and infection.
When irradiated at doses that cause normal mice to die from gastrointestinal problems in about a week, the mutant mice survived a few days longer, until they died from bone marrow failure.

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