[20,21] The bone resorption
is the main culprit for decrease in bone mass once the female attains her menopause.
Many studies have reported that OSAS was associated with an increased level of bone resorption
. In this study, it was also observed that the serum level of [sz]-CTX, a marker of bone resorption
, in the severe OSAS group was significantly higher compared to the obesity group.
Furthermore, antidiabetic medicines such as thiazolidinediones may further promote bone resorption
and increase fracture risk [33-35].
On the other hand, PTH receptors were not identified in osteoclasts or their precursors, indicating that all the effects of PTH on bone resorption
are mediated by osteoblasts (Strewler, 2001).
Osteoclasts synthesize MMP-9 to degrade collagen and their activity is greatly increased during bone resorption
. Glycosylation of type I collagen due to hyperglycemia could be the most probable cause24.
The telopeptides are cleaved during osteoclastic resorption of bone, resulting in their liberation into the circulation at a rate proportional to bone resorption
Inflammation plays a role in bone resorption
, and it is thought that dried plums decrease bone resorption
by inhibiting inflammation.
A healthy bone mass is strictly dependent on the correct balance between osteo-haemostasis functions of increased osteoblastogenesis and decreased bone resorption
, the latter performed by the osteoclasts, multinucleated cells arising from the monocyte/macrophage lineage cells like RAW 264.7 cells (Boyle et al.
Researchers concluded calcium administered during pregnancy and the early postpartum period, to women with intakes around adequacy, was associated with reduced bone resorption
and, thus, may constitute a practical intervention to prevent transient skeletal loss associated with childbearing.
Nasolabial cysts were first described by Zuckerandl in 1882 and histopathological examination was performed by Brown- Kelly in 1898.1-3 Nasolabial cysts are rare non-odontogenic benign lesions in the nasal alar region.13 Although there are giant nasolabial cysts reported in the literature the important aspect of this case is that it was complicated by infection facial deformity and bone resorption
Shirin Hooshmand, PhD, said that while it was difficult to identify the exact mechanism behind dried plums' positive effect on bones, however, this study identified three potential pathways for the mechanism behind the effect of dried plums on bone resorption
and bone formation.
Orthodontic tooth movement is achieved by the process of alveolar bone resorption
on the compression side and new bone formation on the tension side  (Figure 2).