osteogenesis imperfecta

(redirected from brittle-bone disease)
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osteogenesis imperfecta

[¦äs·tē·ō′jen·ə·səs ‚im·pər′fek·tə]
(medicine)
A disease inherited as an autosomal dominant and characterized by hypoplasia of osteoid tissue and collagen, resulting in bone fractures.
References in periodicals archive ?
She took up the position after watching her mother die in pain after years fighting the brittle-bone disease, which strikes one in three women in Britain.
The drug raloxifene came on the market last year, prescribed mainly to counteract osteoporosis, or brittle-bone disease. Approved for use because tests had indicated that it inhibits bone loss, raloxifene nevertheless had not been shown to actually prevent fractures.
Women who have more than four cups a day face a greater risk of osteoporosis, the brittle-bone disease which strikes after the menopause in old age.