A specialized chest radiologist and a pneumologist analyzed the images at three pre-established levels (trachea, carina, and pulmonary veins) for the presence of any signs of diffuse parenchymal lung disease: ground glass, consolidation, reticular, honeycombing, and bronchiectasia
. Biopsy slides were reviewed independently by at least two pathologists and reclassified according to the American Thoracic Society/ European Respiratory Society consensus classification of interstitial pneumonia as described in detail in an earlier report (1).
Additionally, five variables including bronchiectasia
, peribronchial wall thickening, single cavity, multiple cavity, and consolidation were evaluated in terms of lobar distribution (in six lobes) (Table 3).
Questo criterio ha determinato che fossero inclusi negli studi pochi soggetti con BPCO e molti soggetti con diagnosi di bronchiectasia
. Negli studi in cui il volume dell'espettorato e minimo o moderato, non e stato dimostrato un effetto positivo.