Thickening of alveolar septa is seen (Red arrows), as well as chronic inflammation in bronchiolar
wall (Arrow head) (H&E, 10x)
Vascular congestion, epithelial loss and hyaline membrane formation, degenerations and necrosis in bronchiolar
and alveolar cell walls, thickening in interalveolar septum, congestion in capillary walls, mononuclear cell infiltrations can be observed with light microscope (Odabasi,D.2006; Schnells et al.
Five days after inhalation, WD large bronchiolar
inflammatory infiltration was observed and consisted of more than 100 layers of cells (Photo 2a).
At all time points, scattered immunopositive bronchiolar
epithelial cells were observed (arrows).
However, unexpectedly, the results showed that TAZ expression in fibroblasts and bronchiolar
cells was significantly lower in fibrotic type versus cellular type [Figure 1]a and [Figure 1]b.
Toxicokinetics affecting concentrations at the bronchiolar
epithelium substantially drive the risk of bronchiolitis obliterans from irritant gases.
Pathologically, cryptogenic organizing pneumonia was defined by the presence of granulation tissue in the bronchiolar
lumen, alveolar duct, and some alveoli, associated with a variable degree of interstitial and air space infiltration by mononuclear cells and foamy macrophages [1-3].
The entrapped bronchiolar
epithelium was highlighted by AE1/AE3 (Figure 5(i)).
In all WT mice exposed to NA inhalation, airway epithelial cell necrosis was clearly visible in the lung using high-resolution light microscopy, at both time points after termination of exposure, with partial detachment of Club (Clara) cells from the bronchiolar
Babb and Rodarte  have reported that mean bronchiolar
diameter decreases after the age of 40.
The recently defined receptor for MERS-CoV, dipeptidyl peptidase 4 (DPP4), is generally expressed in endothelial and epithelial cells and has been shown to be present on cultured human nonciliated bronchiolar
epithelium cells, providing further information on the respiratory tropism of MERSCoV .
The lymphocytes infiltrated bronchiolar
epithelium forming well-defined lymphoepithelial lesions.