The cellular nodules can lead to destruction of the bronchiolar
wall and adjacent alveolar structures (Figure 4, C).
Smooth muscle contraction in the lung leads to a reduction in bronchiolar
luminal diameter, with secondary infolding of the mucosa, including the basement membrane and elastin fibers (Figure 3, B and C).
walls were moderately infiltrated by neutrophils and had multifocal epithelial necrosis and multifocal peribronchiolar moderate infiltration by macrophages and lymphocytes and few neutrophils and plasmacytes.
In contrast, those influenza viruses which are highly pathogenic toward humans, from the pandemic viruses of 1918 (H1N1), 1957 (H2N2), and 1968 (H3N2) to the subtype H5N1 strains isolated from humans since 2003, additionally colonize the bronchiolar
and alveolar epithelia, preferentially or not, and cause diffuse alveolar damage as an additional primary lesion (20-23).
Ferin and Oberdorster (1992) discussed the role of BALT as a possible site in rats where interstitial particles move out onto the bronchiolar
All patients had open lung biopsies and were studied in detail according to architecture, temporal homogeneity, distribution of lesions, damage to bronchiolar
epithelium, fibroblastic foci, and air space remodeling.
We observed a positive IHC reaction in bronchiolar
epithelia only, which showed severe inflammatory changes (Figure, panel D).
1979), in an experimental study in rats, reported that exposure to fiberglass and styrene induced an alteration of the cells of the bronchiolar
epithelium with a predominance of apocrine cells.
6(p968)) Soon, other diagnostic terms arose within the literature to describe this tumor, including terminal bronchiolar
carcinoma, pulmonary adenomatosis, and terminal bronchiolar
carcinoma; however, none of them ever became popular.
The alveolar and bronchiolar
lumina were filled with alveolar macrophages, neutrophils, and erythrocytes, mixed with fibrin and cellular debris.
Inhalation of particles with a mass median aerodynamic diameter of 10 [micro]m or less is associated with increased hospitalization for asthma, bronchiolar
irritation, and lower respiratory tract infections, while exposure to particles 2.
Thus, the extent of fibrosis in or around the bronchiolar
wall does not appear to be a useful criterion for separating RB and RBILD, and most authors make the distinction on the presence or absence of clinical features of an ILD.