Lefort et al., "Acquirement of brown fat cell
features by human white adipocytes," The Journal of Biological Chemistry, vol.
The gene regulator micro-RNA 155 inhibits a certain transcription factor that controls brown fat cell
AgeX has two preclinical cell therapy programs: AGEX-VASC1 (vascular progenitor cells) for tissue ischemia and AGEX-BAT1 (brown fat cells
) for Type II diabetes.
Research shows that mice with increased numbers of brown fat cells
are lean and protected from obesity, compared with those dominated by white fat.
The compound ST32da, according to the joint study in Taiwan, is said to activate the body's brown fat cells
to speed up weight loss.
For quite some time now, researchers have been trying to develop drugs that can either boost the activity of brown fat cells
or transform white fat cells into tissue that behaves similarly to brown fat, in order to harness brown fat's properties for weight loss.
Brown fat cells
burn energy at a much higher rate than white fat.
Multiple symmetric lipomatosis may be the consequence of defective noradrenergic modulation of proliferation and differentiation of brown fat cells
. J Pathol.
In a small laboratory study, University of Florida researchers found that the hormone irisin can help transform calorie-storing white fat cells into energy-burning brown fat cells
. Irisin appears to work by boosting the activity of genes and a protein that are essential in turning white fat cells into brown cells.
Histologic sections demonstrated cytologically bland brown fat cells
with abundant granular cytoplasm identical to the preoperative biopsy (Figure 5).
Researchers at Leiden University Medical Centre, Netherlands, reckon artificial lights disrupt our body clocks and the brown fat cells
that burn calories.