This erythritol is playing crucial role in the localization of Brucella pathogens to these sites and successive addition of large amounts of secondary bacteria, which causes abortion.
Intracellular Trafficking: Following the Brucella being engulfed by macrophages or invading into non- phagocytic cells, it occupies inside a membrane-bound compartment called as Brucella-containing vacuole (BCV) and then convert into a replicative compartment or brucellosome (Kohler et al., 2002).
Some BCVs are conserving internalized Brucella freight from endocytic compartments and are binding with rough endoplasmic reticulum (RER), where act as niche for intracellular replication of Brucella (Pizarro-Cerda et al., 2000), constituting a distinctive aspect of the intracellular Brucella lifestyle (Fig.
He, "Analyses of Brucella pathogenesis, host immunity, and vaccine targets using systems biology and bioinformatics," Frontiers in cellular and Infection Microbiology, vol.
Taylor, "Liver histology of acute brucellosis caused by Brucella melitensis," Human Pathology, vol.