Most common complications of orf are secondary infection, lymphangitis, lymphadenopathy and erythema multiforme.1 There are a few rare case reports about subepidermal immunobullous disease affecting skin and/or mucous membranes following orf in the literature.4-7 We also present a case from our clinic about bullous pemphigoid
following orf since it is a rare clinical situation.
Incidence of oral candidiasis is more in Pemphigus vulgaris than Bullous pemphigoid
because of the fact that nearly 70% of the cases of Pemphigus vulgaris have oral lesions, whereas only 30% of the Bullous pemphigoid
cases present with oral lesions.
Moreover there are scarce data connected with itch intensity in a course of bullous pemphigoid
Zillikens, "The pathophysiology of bullous pemphigoid
," Clinical Reviews in Allergy & Immunology, vol.
Dmochowski, "Bullous pemphigoid
and neurodegenerative diseases: a study in a setting of a Central European university dermatology department," Aging Clinical and Experimental Research, vol.
To evaluate the disease activity, an ELISA-test was performed, detecting IgG directed against the hemidesmosomal bullous pemphigoid
antigens: BP180 (370 RU/mL) and BP230 (322 RU/mL) (positive if [greater than or equal to] 20 RU/mL).
Dufresne, "Gabapentin-induced bullous pemphigoid
," The Journal of the American Osteopathic Association, vol.
However, a recent study of BSLE patients demonstrated that autoantibodies to other elements of the basement membrane including laminin-5, laminin-6, and bullous pemphigoid
(BP) antigen I are effective in the pathogenesis of BSLE.
is an autoimmune bullous disease characterized by skin lesions, with or without oral lesions.
Methotrexate and compound glycyrrhizin can be an effective alternative therapy in the treatment of erythrodermic psoriasis with bullous pemphigoid
is a disease of the elderly and presents as pruritic tense bullae favoring the flexural creases, and sometimes as erythematous urticarial plaques.
(63) Though the disease may remit after a few weeks after delivery, a protracted course, conversion to bullous pemphigoid
or recurrence with menstrual cycle and use of oral contraceptive pills has been reported.