(2) Consequently, centrally-acting agents that decrease serotonin or increase dopamine, or have some combination of these actions, such as bremelanotide, bupropion, buspirone
, and flibanserin, have been and continue to be under investigation as potential therapies.
She was adamant about staying on buspirone
, as she felt it helped her the most with her anxiety at social events.
He says that neither bupropion nor buspirone
are helping with his depression, anxiety, or any related symptom.
(20) In addition, meperidine can be used with buspirone
and dexmedetomidine to synergistically lower the shivering threshold.
is non-benzodiazepine anxiolytic that was first marketed in 1986.
* Consider buspirone
as an alternative to benzodiazepines for anxiety coexistent with COPD.
Conversely, removal of the host serotonin innervation or pretreatment with a 5-HT1A receptor antagonist did not abolish the anti-GID effect of buspirone
. These results led the authors to suggest that the modulatory effect of buspirone
on GID may be independent of activation of either pre- or postsynaptic 5-HT1A receptors on serotonergic neurons but conceivably due to blockade of DA D2 receptors; indeed, it is known that buspirone
also acts as a DA D2 receptor antagonist [72, 73].
For those patients who do respond to their first therapy but do not get entirely back to normal, an antidepressant with a different mechanism of action (Bupropion or buspirone
) can be added to the initial antidepressant regimen.
Other medications that are 5-[HT.sub.1A] agonists with potential prosexual effects include buspirone
(Buspar) and trazodone (Desyrel, Oleptro).
Altogether, the 12 studies included 1 936 patients and seven kinds of augmentation agents, namely lithium, trifydic antidepressants (TCAs), atypical antipsychotics (AAPs), antiepileptic drugs (AEDs), buspirone
, cognitive behaviour therapy (CBT) and tri-iodothyronine (T3).
As shown in Figure 1, after removing 36 cases due to various exclusion criteria, there were 119 who completed treatment for anxiety and depression, including 63 who received CBT without medication and 56 who received medication (buspirone
, sertraline or both buspirone
and sertraline) without CBT.
For patients who have achieved only partial response to an antidepressant, consider augmenting with a nonantidepressant such as atypical antipsychotics; dopamine agonists and psychostimulants; lithium; thyroid (T3); buspirone
; and natural agents such as L-methylfolate, S-adenosyl-L-methionine (SAMe), creatinine, and omega-3 fatty acids.