busulfan


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busulfan

[‚byü′səl·fən]
(pharmacology)
CH3SO2O(CH2)4OSO2CH3 Crystals with a melting point of 114-118°C; soluble in acetone at 25°C; used as an antineoplastic drug.
References in periodicals archive ?
Pharmaceutical manufacturing company Pharmaceutics International Inc (Pii) revealed on Friday the availability of Busulfan Injection in 6mg/ml in 10ml vials.
The most commonly used cytostatics in the clinic are methotrexate, cyclophosphamide, ifosfamide, cytarabine, busulfan and ciclosporinum.
It is well documented, especially within 5-10 days after initiating a conditioning regimen, mostly with radiation-based myeloablative regimens containing the chemotherapeutic agents busulfan, etoposide, melphalan, and methotrexate, in addition to the use of methotrexate-containing GvHD prophylaxis (10).
Busulfan is used in combination with cyclophosphamide in the treatment of chronic myelogenous leukemia.
? Cancer Research UK helped develop the drugs busulfan and melphalan to treat neuroblastoma and helped fund an international trial showing they could improve survival for children with advanced neuroblastoma.
After complete remission, transplantation was performed from 65-year old fully HLA compatible sister donor with 7.1x10/kg CD34+ peripheral stem cell infusion using Bu12,8Flu180ATGf10 (Busulfan, Fludarabin, Anti-Thymocyte globulin) preparation regimen.
Permanent hair loss is reported with certain drugs such as cyclophosphamide and busulfan. [11] Minoxidil was found to be ineffective in preventing chemotherapy-induced hair loss.
The tolerability of RIC makes it an attractive preparative regimen for allo-HSCT, but the reduced dose or omission of cyclophosphamide, busulfan, and total body irradiation (TBI) raised concerns regarding the immunosuppressive and tumor-ablative potency.
Hastalarin 17'si myeloablatif tedavi (13 hastaya siklofosfamid, IV busulfan; 2 hastaya siklofosfamid, fludarabin, IV busulfan; 1 hastaya melfalan, busulfan; 1 hastaya ATG, fludarabin, siklofosfamid, IV busulfan) verilirken, 4 hastaya dusuk yogunluklu (3 hastaya ATG, fludarabin, siklofosfamid, 1 hastaya ATG, fludarabin, IV busulfan) hazirlama rejimi uygulandi.
After patients underwent myeloablative busulfan conditioning, the cells were reinfused and patients were monitored for adverse events, vector integration, and levels of replication-competent lentivirus.
A systemic analysis of 20 studies (1090 patients) demonstrated an association between the incidence of IPS and the use of high-dose lung irradiation, high-dose cyclophosphamide, and the addition of busulfan (24,26,27).