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Weight loss, weakness, and wasting of the body encountered in certain diseases or in terminal illnesses.



a state of profound wasting and physical debility manifested by severe emaciation, weight loss, dry and flabby skin, loss of hair, disappearance of subcutaneous fat, atrophy of muscles and viscera, and low serum protein level. Edema, hemorrhages, and sometimes mental derangement can occur with cachexia. It results from prolonged malnutrition or starvation, severe metabolic disorders, chronic arsenic, lead, mercury, or fluorine poisoning, and severe lesions of the digestive tract (atrophy of the intestinal mucosa, condition after resection of the stomach and intestines). Cachexia may occur in severe cases of tuberculosis or other chronic infections, some lesions of the endocrine glands, (hypophysis, thyroid, adrenals, pancreas), large slow-healing wounds, abscesses, and malignant tumors (especially of the esophagus and stomach).

References in periodicals archive ?
Interestingly, global inhibition of ER stress and UPR pathways induced muscle wasting in wild-type mice and resulted in a more pronounced cachectic muscle phenotype in tumor-bearing mice [113].
Muscular deconditioning leading to a cachectic state can contribute to the reduced exercise capacity immediately following HT (Anker et al, 1997; Bussieres et al, 1995).
On examination she was apyrexial and looked cachectic. Systemic examination was non-specific and did not reveal and pathological findings.
Thom, "Muscle quality, architecture, and activation in cachectic patients with rheumatoid arthritis," Journal of Rheumatology, vol.
In terms of cancer cachexia, it was hard to assess exactly how many underweight patients after treatment were in cachectic state according to the retrospective analysis of medical records.
On examination, he appeared cachectic and was dehydrated and hypothermic (tympanic temperature 32.9[degrees]C).
In April 1879, Jules Pean of Paris performed a resection of a cancer of the pyloric end of the stomach in a cachectic patient, who died on the fifth postoperative day.
On physical examination, the following were noted: a pale, cachectic, and physically underdeveloped female at 5' 2" and 87 pounds presenting with curvature of the spine; several skin nodules on chest and back; and several facial hemangiomas around the cheeks and chin area.
On examination he was cachectic with an ECOG performance status of 3 and had no palpable lymphadenopathy.
Few of the men were cachectic; the average body mass index was 28 kg/[m.sup.2].
Search Terms Term 1 Cancer or neoplasm or carcinoma or tumo?r Cancer* or neoplasm* or carcinoma or tumour Term 2 Cachexia or cachectic or weight loss or malnourished or wasting Cachex* or cachect* or (weight los*) or malnourished or wast* Term 3 Nutrition or diet Nutrition* or diet* Search = Terms 1 and 2 and 3 Limited to adult humans Search updated with databases available April 2005 Electronic The Cochrane Database of Systematic Reviews databases The Cochrane Central Register of Controlled Trials (CENTRAL) Medline Advanced 1950-2005/01 PubMed (to include early 2005 publications)--Cancerlit CINAHL (1982-current) Web of Science EMBASE Health Source: Nursing/Academic Edition Cancernet Cancer Spectrum Australasian Medical Index (AMI)