TNF

(redirected from cachectin)
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Related to cachectin: tumor necrosis factor, TNF alpha

TNF

(organic chemistry)
References in periodicals archive ?
Cerami and his colleagues report in NAATURE that human TNF and mouse cachectin are nearly identical; human TNF and human cachectin are completely identical, he says.
First Rockefeller University researchers in New York City realized that cachectin, the weight-loss-producing substance they had been working on for years, was essentially the same as tumor necrosis factor, a substance that researchers had isolated using its ability to kill cancer cells (SN: 8/31/85, p.132).
Tumor necrosis factor-[alpha] (TNF-[alpha]) known as cachectin as well was at first discovered by its antitumor activity in 1975.
The first member of TNF superfamily discovered is TNF-alpha (old name cachectin), a pleiotropic proinflammatory cytokine that plays pivotal role in several pathological conditions due to inflammation and infection [2].