Mutation of CDH23, encoding a new member of the cadherin
gene family, causes Usher syndrome type 1D.
The activation of the transcription factor Snail and induction of EMT markers have, as consequence, the upregulation of the mesenchymal marker Vimentin and the downregulation of the epithelial marker E- cadherin
. During the activated EMT program, SGEC exhibit dramatic morphological changes and the gain of mesenchymal properties including increased migratory capacity and contractility.
CDH1 is an original cadherin
and plays a pivotal role in epithelial structure remodeling and maintaining the stemness of stem cells in breast epithelial and cancer cells [5-7, 38-40].
During this process, E-cadherin, a hallmark of the epithelial phenotype, is downregulated, while neural cadherin
(N-cadherin), normally expressed in fibroblasts, is upregulated (Thiery et al., 2009).
We determined the expression of rat Apc, Espn (espin), Cdh2 (cadherin
2), and Vim (vimentin) mRNA using the Roche Universal Probe Library (Roche Applied Sciences, Burgess Hill, UK) [Apc forward primer: 5-CTTCGTGT ACGGCAGCTCTT-3', reverse primer: 5 '-GCAGTTTCATGC TTGC TCTG-3' (probe 127, catalog no.
The study was conducted in 60 cases of invasive ductal carcinoma NOS with 20 cases belonging to each grade and evaluation of p53 was done by IHC and that of HoxD10 and E Cadherin
status by PCR and correlation was done with histological grade and other prognostic factors.
cell adhesion receptors as a morphogenetic regulator," Science, vol.
, a specific marker for the distal portion of the nephron and related renal neoplasms.
Of these, the first two belong to the adherens junctions, where the adhesion molecules cadherin
and catenin are present.
In regard to cadherin
behavior, an interesting finding was the switch to N-cadherin (Figure 2(b)), which is often observed during EMT occurring in metastasizing epithelial tumors .