Expressed recombinant
cadherins mediate cell sorting in model systems.
Role of
cadherins in the transendothelial migration of melanoma cells in culture.
Oas RG, Nanes BA, Esimai CC, Vincent PA, Garcia AJ, Kowalczyk AP p 120-catenin and [beta]-catenin differentially regulate
cadherin adhesive function.
Andrews JL, Kim AC, Hens JR: The role and function of
cadherins in the mammary gland.
To simulate that environment, the researchers used a peptide sequence that mimics these
cadherin interactions, which they bound to the hydrogels used to encapsulate the mesenchymal stem cells.
1),
cadherins form plates or cytoplasmic condensations that are localized near the lateral plasma membranes of adjacent cells.
Downregulation of epithelial
cadherin is required to initiate metastatic outgrowth of breast cancer.
Ultrastructural studies show that E-
cadherin on the cytoplasmic membrane of the keratinocytes is shifted to desmosomes under physiological conditions and therein expresses an adhesion function in association with other desmosomal
cadherins.
The main cell adhesion molecules involved in vertebrate morphogenesis are the
cadherins (Takeichi, 1988).
Finally, treatment of the cells with PLE prevented UV-induced morphological changes in human fibroblasts, namely disorganisation of F-actin-based cytoskeletal structures, coalescence of the tubulin cytoskeleton and mislocalization of adhesion molecules such as
cadherins and integrins.
Cadherins are calcium-dependent glycoproteins that mediate cell-cell interactions by binding to opposing
cadherin molecules on neighboring cells.
The studies on the expression levels of
cadherins have implicated that MT-3 might be involved in epithelial to mesenchymal transition (EMT) that is postulated to occur during several disease states and in the mesenchymal to epithelial transition (MET) that occurs during normal kidney morphogenesis.
