calcitriol


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calcitriol

[‚kal·sə′trī‚ōl]
(biochemistry)
1,25-dihydroxycholecalciferol, the form of vitamin D that is involved in intestinal absorption of Ca2+and Ca2+resorption by bone.
References in periodicals archive ?
Of the neurosteroids involved in brain development, calcitriol is unique--the least understood but arguably one of the most profound.
Calcitriol for bone loss in patients with primary biliary cirrhosis.
ASCENT showed a survival benefit for docetaxel plus calcitriol.
Calcitriol Injection is indicated in the management of hypocalcemia in patients undergoing chronic renal dialysis.
Biopharmaceutical company Rockwell Medical Inc (NASDAQ:RMTI) reported on Monday the submission of data to the FDA for approval to manufacture its injectable active vitamin D drug, Calcitriol.
CYP24A1 breaks down calcitriol, which has a normal and crucial role when kept in check.
The purpose of this study was to: 1) observe the in vitro effects of 10, 100, and 1000 nM concentrations of calcitriol on VSMC calcification in the presence of normal and high phosphate, 2) examine the surface morphology and protein expression of VSMCs given 100 nM calcitriol in the presence of normal and high phosphate, and 3) observe the in vitro effects of combinations of calcitriol, FGF-23, and soluble klotho on VSMC calcification in the presence of high phosphate.
Moreover, the increased FGF23 markedly inhibits the action of the proximal tubular 1a-hydroxylase enzyme responsible for the conversion of calciferol to calcitriol (1,25[(OH).
Certain recent studies have shown how calcitriol enhances the antimicrobial effects of macrophages and monocytes, which are important effector cells, fighting against pathogens such as Mycobacterium tuberculosis.
sup][6] The etiology of hypercalcemia might be related to elevated serum calcitriol concentrations due to activated macrophages in granulomas.
Patient received topical Calcitriol ointment with topical emollient for 15 days without change in dose of Nilotinib.
The vitamin D analogs alfacalcidol and calcitriol also don't reduce hip or nonvertebral fractures (SOR: A, multiple randomized, controlled trials [RCTs]), although alfacalcidol (but not calcitriol) does reduce vertebral fractures by 43% (SOR: B, one RCT and one quasi-randomized trial with potential for bias)
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