However, when they blocked glycolysis, they saw a reduced supply of ATP which inhibited the calcium pump
, resulting in a toxic calcium overload and ultimately cell death.
Another prediction is that if spawn time is regulated by reaching a low threshold value of calcium and achieved by endoplasmic reticulum calcium pumps
acting in darkness, a shift in spawn time would result from either changing the rate at which calcium is sequestered or changing the sensitivity of a cytoplasmic process to calcium levels.
'It turns out that the calcium pump
can accurately measure the cell's calcium content and adjust its speed in accordance with this information.
Electron microscopy reveals loss of desmosomes (epithelial intercellular junctions formed by membrane and submembrane protein complexes), breakdown of desmosome-keratin intermediate filament attachment, and perinuclear aggregates of keratin intermediate filaments.7,8 The mechanism by which decreased activity of the SERCA2 calcium pump
leads to these changes is still under investigation.
In young hearts, these calcium pumps
work quite well, but in older hearts these pumps are much less efficient.
In the presence of calbindin D, there is an increase in transmembrane calcium pump
activity within the membranes of the intestine and the distal tubule of the nephron.
Abnormal red-cell calcium pump
in patients with idiopathic hypercalciuria.
Leading researchers from Aarhus University and the University of Copenhagen have now provided new information of how the calcium pump
regulates the amount of calcium in the cells.
PROTEINS--Proteins on the sarcoplasmic reticulum that remove calcium from the cell cytosol after a contraction.
This review mainly focuses on the structure, function of the sarco(endo)plasmic reticulum calcium pump
(SERCA) and its role in genesis of arrhythmias.