Calcium pyrophosphate dihydrate crystal deposition disease--1975.
Calcium pyrophosphate deposition disease (CPPD) is a condition that is characterized by the deposit of pyrophosphate crystals into tendons, ligaments, cartilage and synovium.
Bullough, "Tophaceous pseudogout (tumoral
calcium pyrophosphate dihydrate crystal deposition disease)," Human Pathology, vol.
In the 1960s, McCarty et al (12,13) discovered new crystals in the synovial fluid, which were
calcium pyrophosphate dihydrate.
Two patients showed
calcium pyrophosphate crystals on polarized microscopy and two had no bacterial growth or crystals.
Haemochromatosis, rheumatoid metacarpophalangeal joints arthritis Prolonged stiffness after rest Inflammatory arthropathy including rheumatoid arthritis Rheumatoid factor positive Rheumatoid arthritis but low titre RF is often seen in the elderly Chondrocalcinosis on plain
Calcium pyrophosphate disease X-rays
Psendogout: Similar to gout; however, the crystals in the synovial fluid are composed of
calcium pyrophosphate dihydrate and not uric acid.
Calcium pyrophosphate dihydrate deposition in the intervertebral discs in a case of Wilson's disease.
Calcium pyrophosphate deposition disease (CPDD) is a crystal arthropathy caused by the deposition of
calcium pyrophosphate dehydrate in and around joints, particularly in articular cartilage and fibrocartilage.
Unlike in rheumatoid arthritis or secondary OA due to hemochromatosis,
calcium pyrophosphate disease, or trauma, there is no metacarpophalangeal joint or wrist involvement, stressed Dr.
However,
calcium pyrophosphate dehydrate deposition disease (CPPD) and rheumatoid arthritis are the differential diagnoses, which need to be evaluated both clinico-radiologically and with a histopathological examination.
Synovial fluid should be aspirated and analyzed if a palpable effusion is present, in order to confirm or exclude inflammatory disease and identifyurate and
calcium pyrophosphate crystals.
