calpain


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Related to calpain: cathepsin, calpastatin

calpain

[′kal‚pān]
(cell and molecular biology)
A calcium-dependent cysteine protease in the cytoplasm that is central to most processes in cell biology (plasma membrane-associated signaling events; cell proliferation, differentiation, activation, and communication; and programmed cell death). Its overactivation has been observed in muscular dystrophy, Alzheimer's disease, AIDS, cataract formation, multiple sclerosis, and arthritis.
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The optimum proteolytic activity of calpains was observed in the fresh meat of red deer - 0.085 um/h for one gram of protein (Fig.
Murphy, "Calpains, skeletal muscle function and exercise," Clinical and Experimental Pharmacology and Physiology, vol.
Cells were serum-deprived for 24 hours and subsequently incubated for 30 min in the presence of BAPTA-AM (10 [micro]M) or the calpain inhibitors: calpastatin (1 [micro]M) or PD1506060 (100 [micro]M), followed by stimulation with either thrombin or PAR1-AP in DMEM/F12 medium for 5 minutes at room temperature.
Guarnier performed the measurements of the calpain activity and carbonyl protein content.
Lee, "Synthesis of chromone carboxamide derivatives with antioxidative and calpain inhibitory properties," European Journal of Medicinal Chemistry, vol.
reported their novel findings that calcineurin, together with its upstream molecule, calpain 2, and downstream effector, NFAT-c3, plays a critical role in the development of AF in patients with vascular heart disease and diabetes.
Most muscular dystrophies (MDs) are caused by mutations in genes such as dystrophin, dysferlin, calpain, or LARGE like-glycosyltransferase [7-12].
Calpain activities required in the myoblast fusion process and the proliferation of cell growth [15].