More importantly, chemotherapy drugs (camptothecin
, taxol, etoposide, and cisplatin) were PPAR[alpha] dependent-induced autophagy formation; similar results observed that agonist/PPAR[alpha]/cisplatin signaling enhanced autophagy and subsequently promoted cancer cell chemotherapy sensitivity and tumor suppression.
It has been used to extract camptothecin
and hydroxycamptothecin from Camptotheca acuminata leaves  and isoflavones from soybean meal , which has been proved to be an effective extraction method.
The utility of camptothecin
as a synergist of Bacillus thuringiensis var.
Present study presented the inhibitory effect and mechanism of the plant alkaloid camptothecin
There are a number of medicines derived from plants such as vinblastine, vincristine, Madagascar periwinkle, capsaicin from chili pepper, and paclitaxel from Pacific yew while few chemically altered lead molecules derived from plants are dicoumarol (warfarin), artemisinin (artemether), camptothecin
(irinotecan and topotecan), morphine, and salicylic acid (acetylsalicylic acid).
(20 [micro]M) and digitonin (80 [micro]M) were used as positive controls for apoptosis and necrosis, respectively.
was from Tocris (Eching, Germany); Triton-X 100, milk powder, and N,N,N',N'-tetramethyl-1-,2-diaminomethane (Temed) were from Carl Roth (Karlsruhe, Germany); DMSO, lipopolysaccharide (LPS), phorbol, 12-myristate 13-acetate, CFSE, ammonium persulfate, bovine serum albumin, ethanol absolute, hydrochloric acid (37%), leupeptin hemisulfate, p-coumaric acid, pepstatin A, Ponceau S, trypan blue, Tween 20, and ionomycin were from Sigma-Aldrich (Taufkirchen, Germany).
Yang, "Body distribution in mice of intravenously injected camptothecin
solid lipid nanoparticles and targeting effect on brain," Journal of Controlled Release, vol.
Uniform spherical nanoparticles with BSA-PMMA core and layers were prepared by precipitation to encapsulate camptothecin
. The camptothecin-loaded BSA-PMMA nanoparticles showed antitumor activity improvement in both in vitro and in vivo studies, reducing the tumor growth around 79%, being more effective than free drug.
(CPT) inhibits cancer cells by the same mechanism as HCPT, HCPT is more active and less toxic .
Cyclodextrin-based nanosponges encapsulating camptothecin
: Physicochemical characterization stability and cytotoxicity.
Some endophytic fungus can produce alike biological active compounds as the host, for example taxol (Stierle et al.,1993), capsaicin (Devari et al., 2014) and piperine (Chithra et al., 2014) and some produce drug like camptothecin
(Singh et al., 2013) etc.