Overall, the antifungal activity of camptothecin
UPDATE: Although it didn't prove effective against leukemia, a synthetic version of camptothecin
is used to treat ovarian, lung and colon cancers.
Correlations between S and G2 arrest and the cytotoxicity of camptothecin
in human colon carcinoma cells," Cancer Research, vol.
isolated from the bark and stem of Camptotheca acuminate is a cytotoxic quinoline alkaloid which inhibits the DNA enzyme topoisomerase I (55).
The other camptothecin
isolates caused a 3-5-fold increase in apoptotic death and also 1.
Several anticancer agents including Taxol, vinblastine, vincristine, the camptothecin
derivatives, topotecan and irinotecan, and etoposide derived from epipodophyllotoxin are in clinical use all over the world.
Currently this study is focused on another target of Camptothecin
(CPT), 10-Hydroxycamptothecin (10-HCPT), 9-Nitrocamptothecin molecules.
The new assay has demonstrated that blue-fluorescent small molecule compounds, such as camptothecin
, strongly interfere with nuclear condensation measurement based on Hoechst dye, but do not impact Enzo's Nuclear-ID Green assay.
When Gb3 was incorporated into VT500 cells through reconstitution with fusogenic liposomes, the reconstituted cells became sensitive to the apoptosis inducer camptothecin
as determined by JC-1 staining for mitochondrial membrane depolarization.
The chemical created so much excitement that the government turned over federal land in Chico to cultivate Camptotheca acuminata, the Chinese shrub from which camptothecin
Remaining papers are presented under the heading "plants as drug factories" and include such topics as intellectual property protection of plant biotechnology, breeding of medicinal plants, camptothecin
production in cell cultures of Ophiorrhiza, and biological production of artemisinin for malaria therapy.
United States Patent 7,151,179, entitled "Process for the Preparation of 7-Alkyl-10-Hydroxy-20(S)- Camptothecin
," was issued on December 19, 2006 by the United States Patent and Trademark Office.