They first determined that several copies of Arc self-assemble into hollow virus-like capsids
and stash its own genetic material, in this case mRNA, inside them.
These viral variants could play an important role in the disease progression to FH by causing excessive accumulation of viral capsids
2010) Galaway&Stockley also showed that VLPs reassembled in vitro with the RNA bacteriophage MS2 coat protein and an RNA conjugate encompassing a siRNA and a known capsid
assembly signal can be targeted to HeLa cells by protecting from nuclease.
A detailed description of the complete HIV capsid
will provide a roadmap for developing drugs that can disrupt its formation and thus prevent infection by HIV.
Because ozone mainly causes capsid
protein damage, viruses with different capsid
protein architecture were assessed.
Then, by having the computer repeatedly shuffle those disks into arbitrary arrangements on a spherical surface, they simulated the formation of millions of hypothetical capsids
AAV naturally exists as several different serotypes, which differ physically in the composition of their capsid
proteins and genome structures.
The polyprotein subsequently undergoes cleavage mediated by a viral protease (3[C.sup.pro]), resulting in the production of four capsid
proteins (VP1-4) and several nonstructural proteins.
"Although viral capsids
have been used for targeted drug delivery and as a vaccine platform, they didn't evolve for that," said Baker.
"When these viruses invade cells, the capsids
get taken inside and never completely break apart," said lead researcher Jane Tao, assistant professor of biochemistry and cell biology at Rice.
The study reported here looked at new molecular approaches for detecting both intact and functional virus capsids
and intact and functional--that is, replicating or transcribable--nucleic acids.