[30] have also found changes in
carbamoyl phosphate 1 expression in IUGRs.
In the urea cycle, OTC combines ornithine and
carbamoyl phosphate to form citrulline.
(1,2) This antigen was shown to be
carbamoyl phosphate synthetase 1, an enzyme involved in urea synthesis.
To overcome any serendipity, positive controls such as acetyl phosphate,
carbamoyl phosphate, dihydroxyacetone-P, phosphoramidate, and monophosphoimidazole were used throughout the docking procedure.
Understanding
carbamoyl phosphate synthetase deficiency: impact of clinical mutations on enzyme functionality.
OTC [EC: 2.1.3.3], a mitochondrial enzyme expressed in liver and gut, catalyzes the condensation of ornithine with
carbamoyl phosphate to form citrulline within the urea cycle.