levodopa

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Related to carbidopa: Entacapone

levodopa:

see l-dopal-dopa
, drug used to alleviate some of the symptoms of Parkinson's disease, particularly trembling, rigidity, and slow movements; the drug is also called levodopa. Parkinson's disease results when the concentration of dopamine in the brain is depleted (see catecholamine).
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levodopa

[¦lev·ə¦dō·pə]
(pharmacology)
C9H11NO4 Crystals or crystalline powder, soluble in dilute hydrochloric acid and in formic acid; used as an anticholinergic drug and in the treatment of Parkinson's disease. AbbreviatedL-dopa.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Maini Rekdal speculated that carbidopa may not be able to penetrate the microbial cells or the slight structural variance could prevent the drug from interacting with the bacterial enzyme.
Gupta, "Effect of concomitant medications on the safety and efficacy of extended-release carbidopa levodopa (IPX066) in patients with advanced Parkinson's disease: a post hoc analysis," Clinical Neuropharmacology, vol.
According to the researchers, the recommended dose of carbidopa for Parkinson's disease patients is 200 mg/day, but when given at a dose even as high as 450 mg/day, there are no side effects.
Carbidopa then lowers the amount of levodopa that is required by the body and can reduce some of the side-effects of levodopa, like nausea and vomiting.
In a paper (containing 90 scientific references) published in Clinical Pharmacology, Hinz, Alvin Stein, and Ted Cole note that the only indication for carbidopa and benserazide is the management of L-dopa-induced nausea.
The Phase II trial, being conducted in the U.K., is a multi-centre, randomized, double-blind, placebo-controlled, dose response, factorial 12-arm parallel group study evaluating 120 patients equally randomized to receive Droxidopa monotherapy, carbidopa monotherapy, Droxidopa/carbidopa combination therapy or placebo.
The second objective was to present a suitable and rapid method in order to measure carbidopa medicine based on electrochemical methods."
Double-blind trial of levodopa/carbidopa/entacapone versus levodopa/ carbidopa in early Parkinson's disease.
The agency is evaluating data from the Stalevo Reduction in Dyskinesia Evaluation--Parkinson's Disease (STR1DE-PD) study, which found that over a mean of almost 3 years, the number of prostate cancers diagnosed among the men treated with entacapone, carbidopa, and levodopa (marketed as Stalevo) was about four times higher than the cases diagnosed among those treated with the carbidopa and levodopa combination product (marketed as Sinemet).
A statement posted on the agency's Web site on March 31 announced that the FDA is evaluating data from the Stalevo Reduction in Dyskinesia Evaluation-Parkinson's Disease (STRIDE-PD) study, which found that over a mean of almost 3 years, the number of prostate cancers diagnosed among the men treated with entacapone, carbidopa, and levodopa (marketed as Stalevo) was about four times higher than the cases diagnosed among those treated with the carbidopa and levodopa combination product (marketed as Sinemet).
For occasional RLS (less than twice per week), he advises either a half or whole tablet of carbidopa 25 mg/levodopa 100 mg (available as Sinemet and Parcopa brands) as needed for first-line therapy.
has received regulatory approval for its abbreviated new drug application for carbidopa and levodopa tablets, USP in a number of strengths.