levodopa

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Related to carbidopa: Entacapone

l-dopa

l-dopa (ĕl-dōˈpə), drug used to alleviate some of the symptoms of Parkinson's disease, particularly trembling, rigidity, and slow movements; the drug is also called levodopa. Parkinson's disease results when the concentration of dopamine in the brain is depleted (see catecholamine). Medical administration of dopamine itself is ineffective since that chemical apparently does not enter the brain from the blood. A metabolic precursor of dopamine, l-dopa does enter the brain via the bloodstream and is probably converted into dopamine there. Because there are many brain disorders with similar symptoms, many patients do not show any improvement when treated with the drug. Virtually all patients on l-dopa experience side effects including nausea, loss of appetite, cardiac irregularities, and psychological changes.

levodopa

[¦lev·ə¦dō·pə]

(pharmacology)

C₉H₁₁NO₄ Crystals or crystalline powder, soluble in dilute hydrochloric acid and in formic acid; used as an anticholinergic drug and in the treatment of Parkinson's disease. AbbreviatedL-dopa.

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References in periodicals archive ?

Maini Rekdal speculated that carbidopa may not be able to penetrate the microbial cells or the slight structural variance could prevent the drug from interacting with the bacterial enzyme.

Gut Microbes Eat Our Medication

Gupta, "Effect of concomitant medications on the safety and efficacy of extended-release carbidopa levodopa (IPX066) in patients with advanced Parkinson's disease: a post hoc analysis," Clinical Neuropharmacology, vol.

Dosing Patterns during Conversion to IPX066, Extended-Release Carbidopa-Levodopa (ER CD-LD), in Parkinson's Disease with Motor Fluctuations

According to the researchers, the recommended dose of carbidopa for Parkinson's disease patients is 200 mg/day, but when given at a dose even as high as 450 mg/day, there are no side effects.

This Parkinson's disease drug shows anticancer effects: Study

Carbidopa then lowers the amount of levodopa that is required by the body and can reduce some of the side-effects of levodopa, like nausea and vomiting.

Wonder drug joy for city pensioner

In a paper (containing 90 scientific references) published in Clinical Pharmacology, Hinz, Alvin Stein, and Ted Cole note that the only indication for carbidopa and benserazide is the management of L-dopa-induced nausea.

Nevada homeopathic and integrative medical association 2014 conference: part 3

The Phase II trial, being conducted in the U.K., is a multi-centre, randomized, double-blind, placebo-controlled, dose response, factorial 12-arm parallel group study evaluating 120 patients equally randomized to receive Droxidopa monotherapy, carbidopa monotherapy, Droxidopa/carbidopa combination therapy or placebo.

CHELSEA THERAPEUTICS INITIATES PHASE II OF DROXIDOPA IN FIBROMYALGIA

The second objective was to present a suitable and rapid method in order to measure carbidopa medicine based on electrochemical methods."

New Hopes for Effective Treatment of Parkinson's by Using Carbon Nanotubes

Double-blind trial of levodopa/carbidopa/entacapone versus levodopa/ carbidopa in early Parkinson's disease.

Q / which drugs work best for early Parkinson's disease?

The agency is evaluating data from the Stalevo Reduction in Dyskinesia Evaluation--Parkinson's Disease (STR1DE-PD) study, which found that over a mean of almost 3 years, the number of prostate cancers diagnosed among the men treated with entacapone, carbidopa, and levodopa (marketed as Stalevo) was about four times higher than the cases diagnosed among those treated with the carbidopa and levodopa combination product (marketed as Sinemet).

Cancer linked with Parkinson's Rx

A statement posted on the agency's Web site on March 31 announced that the FDA is evaluating data from the Stalevo Reduction in Dyskinesia Evaluation-Parkinson's Disease (STRIDE-PD) study, which found that over a mean of almost 3 years, the number of prostate cancers diagnosed among the men treated with entacapone, carbidopa, and levodopa (marketed as Stalevo) was about four times higher than the cases diagnosed among those treated with the carbidopa and levodopa combination product (marketed as Sinemet).

Cancer tie to PD drug investigated

For occasional RLS (less than twice per week), he advises either a half or whole tablet of carbidopa 25 mg/levodopa 100 mg (available as Sinemet and Parcopa brands) as needed for first-line therapy.

Frequency, painfulness of restless legs must guide treatment

has received regulatory approval for its abbreviated new drug application for carbidopa and levodopa tablets, USP in a number of strengths.