carcinogenesis


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Related to carcinogenesis: chemical carcinogenesis

carcinogenesis

[‚kärs·ən·ō′jen·ə·səs]
(cell and molecular biology)
The processes of tumor development.
References in periodicals archive ?
The definition of Carcinogenesis to be consequent in failure of tissue development - by Dr.
Tambien, se han incluido a las criptas que acumulan [beta]-catenina como nuevos biomarcadores de la carcinogenesis colonica en ratas, por su fuerte predisposicion al cancer de colon (10, 16).
Epigenetic alternations, such as chromatin remodeling, have been observed and described in the pathways of GC carcinogenesis, which include such as chromosomal instability and microsatellite instability pathway, [beta]-catenin/Wnt, TGF[beta]/SMAD, and RAF/RAS/MAPK intermediary pathway (10-12).
Professor Ken Yung said, "The novel matrix enables scientists to cultivate NSCs by adopting the usual method, however with the added advantage of organic compounds (like Polylysine and Polyornithine) being excluded from the process, thereby reducing the potential risk of carcinogenesis or inflammation in stem cell therapy.
In colitis-associated cancer (CAC), an example of inflammatory bowel disease- (IBD-) related CRC, chronic inflammation predisposes to carcinogenesis through signalling pathways involving wnt/[beta]-catenin, K-ras, nuclear factor-[kappa]B (NF-[kappa]B), and downstream cytokines [5].
In this study, we identified the IGENs in normal bladder cells and bladder cancer cells and then investigated the impact of epigenetic regulation and miRNA regulation on bladder carcinogenesis by comparing the IGEN in normal bladder cells with that in bladder cancer cells.
Since insulin has pro-proliferative activity and activation of insulin signaling axis has been implicated in carcinogenesis, [sup][5] some researchers proposed that the use of insulin by diabetic patients might contribute to cancer development.
ApcMin mice possess a heritable Apc gene mutation which is responsible for adenoma mutation and serve as a model for colorectal carcinogenesis, the company added.
reported in 2010 that the inhibition by kaempferol of phosphatidylinositol 3-kinase (PI3K) activity, a key factor in carcinogenesis, and its concomitant effects may account for the chemopreventive activity of the flavonol (Carcinogenesis 2010;31:1338-43).
Whereas the genetic contribution to carcinogenesis is generally established, emerging evidence from both the authors Laboratory and others strongly suggest an inflammatory role for prostate carcinogenesis in animal and clinical studies [8-10, 18, 19].
Animal models may reveal mechanisms of viral carcinogenesis.