The genetic toxicology testing battery has been designed to be highly sensitive in predicting chemical carcinogenicity
. The genetic toxicology testing battery detects 93% of carcinogens (Kirkland et al.
The report deals with only a fraction of the potentially carcinogenic agents found in today's workplaces, most of which have sufficient evidence of carcinogenicity
in animals but limited evidence for carcinogenicity
KEY WORDS: animal, carcinogen, carcinogenesis, epidemiology, human, IARC, mechanisms of carcinogenicity
The central hypothesis underlying our study design was that the long-term carcinogenicity
of chemicals can be accurately predicted from gene expression profiles of short-term in vitro models.
Humans are not big mice so relying on rodent data to predict human carcinogenicity
can be flawed.
Pharmaceutical company BioPharmX Corporation (NYSE American:BPMX) revealed on Thursday that the US Food and Drug Administration has waived its requirement for several years of non-clinical research of dermal carcinogenicity
study for BPX-01 normally required for its review.
The International Agency for Research on Cancer classifies talc that contains asbestos as "carcinogenic to humans," while talc not containing asbestos is "not classifiable as to carcinogenicity
in humans." Perineal use of talc-based body powder is classified as "possibly carcinogenic to humans."
Alternative approaches range from the individual test methods (e.g., the cell transformation assay for carcinogenicity
and the zebrafish and embryonic stem cell embryotoxicity tests for reproductive toxicity) to animal reduction approaches such as the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) strategy for carcinogenicity
of pharmaceuticals and the extended-one-generation reproductive toxicity study.
Their topics include alternative methods in haematopoietic stem cell toxicology, the high-throughput screening of toxic chemicals on neural stem cells, toxicological risk assessment: a proposed assay platform using stem and progenitor cell differentiation in response to environmental toxicants, pesticides and hematopoietic stem cells, distributed stem cell kinetotoxicity: a new concept to account for the human carcinogenicity
of non-genotoxic environmental toxicants, and cancer stem cells as therapeutic targets.
of drinking coffee, mate, and very hot beverages.
Food and Drug Administration (FDA) asked the National Toxicology Program (NTP) to conduct toxicology and carcinogenicity
tests linked to exposure to "radio frequency radiation emitted by wireless communication devices, especially cellphones." To test for its potential carcinogenicity
on humans, rats were exposed to radiation for periods of up to two years.