Starting from the 1990s, the Cesare Maltoni Cancer Research Centre (CMCRC) of the Ramazzini Institute (RI) performed carcinogenicity
studies on low doses of chemical or physical agents that may expose millions or even billions of people to potential carcinogenic risks, such as radiations and food additives (Maltoni et al.
In 1991, the IARC assessed the carcinogenicity
of coffee, classifying it as 'possibly carcinogenic to humans' based on limited evidence from case-control studies and data from experimental animals.
Alistair Currie, policy officer for People for Ethnic Treatment of Animals (Peta) said: "The current animal test for carcinogenicity
is primitive, cruel and useless.
Ideally clinical trials should include carcinogenicity
as a primary outcome measure, and longitudinal trials should examine carcinogenicity
of classes of drugs and specific agents, in order to give clinicians a better sense of the risk/benefit equation when prescribing psychotropic agents, he recommended.
A preliminary EPA finding indicated "potential systematic toxicity and carcinogenicity
Sinatra (1) touched on the issue of carcinogenicity
related to these medications.
Executive summary; Background; Objectives of the Consultation; Methods of analysis; Formation and fate of acrylamide in food; Dietary exposure; Absorption, metabolism, distribution and excretion; Non-cancer toxicity; Carcinogenicity
(including genotoxicity and mechanisms of carcinogenicity
); Conclusions and recommendations: Annex 1: List of participants; Annex 2: Agenda; Annex 3: List of major documents used by the Consultation; Annex 4: Abbreviations.
The ToxScope toxicity databases encompass acute toxicity, hepatotoxicity, mutagenicity and carcinogenicity
Environmental Protection Agency (EPA) has concluded that available science does not support the continued identification of peroxides as a new chemical category presenting concerns for possible carcinogenicity
The International Agency for Research on Cancer (IARC) in Lyon, France, part of the World Health Organization, recently decided to reclassify DEHP plasticizer (also known as DOP) as a Group 3 agent--"not classifiable as to carcinogenicity
12] The results of carcinogenicity
assays have been equivocal, but the dye does appear to act as a tumor promoter.
The book includes an introduction to the regulations governing the labeling and use of chemicals, together with definitions of toxicity, carcinogenicity
, mutagenicity and effects on reproduction.