carcinoid syndrome


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Related to carcinoid syndrome: Carcinoid tumor

carcinoid syndrome

[′kärs·ən‚ȯid ′sin‚drōm]
(medicine)
A complex of symptoms arising from the metastasis of a carcinoid tumor to the liver.
References in periodicals archive ?
Carcinoid syndrome affects fewer than 10% of patients with carcinoid tumors.
- Carcinoid syndrome - includes flushing of the skin, diarrhea and wheezing
Patients with carcinoid syndrome display a shorter overall survival (median, 5 years) than patients without carcinoid syndrome (5.6 years) [2].
10% of carcinoid syndrome cases may metastasize to liver or lungs and manifest by erythema on upper torso and face due to the secretion of vasoactive amines, abdominal pain, diarrhea, cramps, and attacks of asthma due to the activation of vasoactive amines like serotonin [15].
Indeed, none of them had carcinoid syndrome. It is noteworthy to report that for most of the observation time the evidence of an anti-proliferative effect of the somatostatin analogs was still uncertain, while now, at least for most of the NETs arising from the digestive tract, this is a demonstrated cornerstone.
David Meek, chief executive officer, Ipsen said, 'We are delighted to provide patients suffering from inadequately controlled carcinoid syndrome with a new treatment option in combination with a somatostatin analogue that demonstrates both efficacy and safety in particularly improving diarrhoea, a most debilitating symptom.
Excluding cardiac valvular lesions, the main symptoms of the typical carcinoid syndrome with cutaneous flushing, venous telangiectasia, diarrhoea, and bronchospasm were present for about 2 years in our patient.
Fourteen (21.9%) patients had associated syndrome, 9 had insulinoma syndrome, 2 had hypergastrinemia (Zollinger-Ellison syndrome (ZES)), and 3 had carcinoid syndrome due to serotonin hypersecretion.
Up to 20% of patients with NETs may develop carcinoid syndrome: flushing, abdominal pain, diarrhea, bronchoconstriction, and carcinoid heart disease [6].
In the presence of liver metastases, or when the primary lesions are found in the bronchus and/or ovaries, 5-HT is not efficiently metabolized by the liver, leading to the development of the carcinoid syndrome (CS) [17, 18].