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The deterioration of existing defense mechanisms, leading to an exacerbation of pathologic behavior.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



disturbance of the activity of an organ, a system of organs, or the entire organism, as a result of exhaustion or disruption of its adaptive mechanisms.

Harmful influences that cause significant changes in the organism disturb the constant equilibrium between the organism and the external environment. After some time, the organism adapts itself to the new conditions of existence (for example, the heart muscle hypertrophies when there are heart defects) and equilibrium is restored—that is, compensation occurs. When there is compensation, the organ (or system) works under an increased load, as a result of which it succumbs more readily to harmful influences.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
The increased activity of the cardiac decompensation mechanism of respiratory failure patients (renin-angiotensin-aldosterone system) and the sympathetic nervous system cause myocardial hypertrophy and ventricular remodeling, resulting in a vicious cycle.7,8
Maternal heart disease can lead to cardiac decompensation and death, particularly in the second stage of labour.
In the presence of a left atrial myxoma, the hemodynamic changes caused by the mitral stenosis-like effect of the myxoma concomitant with the circulatory burden of pregnancy may result in cardiac decompensation and congestive heart failure and lead to the death of the mother or fetus.
Her cardiac decompensation resolved over several days and an ejection fraction of 70% was noted on echocardiogram 10 weeks after her admission.
The Heart Failure Monitor has a number of settings, including a thoracic impedance feature that predicts imminent cardiac decompensation, heart failure and helps physicians to prevent hospitalization.
Having detected a murmur in the mitral valve of the patient's heart, the pulmonologist believed that the patient was most likely suffering from a mitral-valve disease that was causing cardiac decompensation. The patient was in stable condition when the pulmonologist examined him at 5:00 p.m., but the doctor characterized him as a "really sick guy" and expected him to be cared for by a cardiologist.
In deciding on the method of anaesthesia for caesarean section or analgesia for labour, the risks of the various techniques must be considered in light of the patient's condition, in particular the presence of spinal AVMs or acute cardiac decompensation, with few publications about the anaesthetic management of parturients with high output cardiac failure secondary to AVMs.
Once intracardiac injury is detected, early surgical repair is recommended to prevent cardiac decompensation and endocarditis (3, 4).
There was further cardiac enlargement after exercise, attributed to cardiac decompensation and "cardiac fatigue." "Bleeding from the mouth or nose did not occur" (6), a reference to the absence of pulmonary edema and an indicator of the authors' concern about cardiac failure (6).
These events may precipitate late cardiac decompensation. Therefore, she concluded by pointing out that we do not know the true time course of cardiotoxicity or its relationship to early markers of cell loss such as troponin.
In parallel with changes in cardiac physiology, there are three periods of particular high risk for cardiac decompensation during pregnancy.
This causes sometimes complications like cardiac decompensation or disturbances of the circular system, which cannot be handled any more by ophthalmologists.