As per protocol of treatment of these tumors, all patients with diagnosed carotid body
tumors were assessed clinically to rule out functional tumors.
Etiopathogenesis and clinical presentation of carotid body
In this sense, adult stem cells from the carotid body
taken from the neural crest (CBSCs) are capable of experiencing endothelial differentiation, as well as their already described role in neurogenesis.
Her mass was mistaken for a carotid body
tumor and it was treated as it was really a CBT.
The presence of a pulsatile anterior neck mass leads to suspicion of vascular anomalies like arteriovenous (AV) fistula, aneurysms, pseudoaneurysms, and carotid body
tumor presenting with carotid sinus syndrome.
Studies [74, 75] have shown that hypoxia-induced carotid body
dysfunction is related to processes such as the upregulation of renin-angiotensin system, inflammation in the carotid body
, and oxidative stress.
A growing amount of evidence suggests that the carotid chemoreflex elicited by arterial chemoreceptors in the carotid body
in response to episodes of hypoxia (intermittent hypoxia) in sleep apnea plays a role in the pathophysiological cascade .
Researchers at Britain's Bristol University found that in rats with high blood pressure, when they removed nerve links between the brain and the carotid body
- a nodule about the size of a grain of rice on the side of each carotid artery - the animals' blood pressure fell and remained low.
The carotid body
is a small nodule- no larger than a rice grain- found on the side of each carotid artery and it appears to be a major culprit in the development and regulation of high blood pressure.
Objective: Carotid body
tumors (CBTs), especially familial paragangliomas, are rare benign neoplasm, accounting for less than 0.5% of all tumors; and they are the most common extra-adrenal paraganglioma.
In the head and neck, these tumours are often mistaken for other lesions such as enlarged lymph nodes, carotid body
tumours, branchial cysts, or thyroid lesions (2,3).