The proposed USP monograph for Albuterol Inhalation Aerosols, specifies a non-standard sampling apparatus for delivered dose uniformity (DDU) testing, and an alternative to the standard USP induction port for aerodynamic particle size distribution (APSD) measurement using an Andersen Cascade Impactor
With cascade impactor
we explain about deposition site and rate from particle size spectrums.
The company is a specialist in cascade impactor
technology with products serving the pharmaceutical and aerosol research markets, as well nano-particle generation and measurement technology serving the semiconductor device fabrication market.
To investigate the size distributions of aerosol particles responsible for transport of endotoxins and peptidoglycans, the air samples were additionally collected using the 8-stage cascade impactor
(model 20-830, New Star Environmental, Inc., Roswell, GA, USA), which can separate particles of the following aerodynamic diameters: 0.4/0.7/1.1/2.1/3.3/4.7/5.8/9 [micro]m.
PM course and fine fractions can be collected with cyclones and cascade impactor
. Cyclone separates and collects air particles of certain sizes such as [PM.sub.10], [PM.sub.2.5] or [PM.sub.1.0], among others, while cascade impactor
separates and collects particles in size ranges.
The methods available for collecting fungal for this research are used biostage single-stage impactor viable cascade impactor
attached to a SKC Quick Take 30 are.
In combination with the BAC 2000, a timer-controlled solenoid valve used as part of the system for determining the APSD of PF Inhalation Powders, these accessories enable standard test equipment, including the Andersen Cascade Impactor
, to be tailored to meet the specifications of the new monographs.
Powders aerodynamic properties were assessed by Andersen cascade impactor
(apparatus D, Eur.
Rapid check of cascade impactor
cut-sizes using a polydisperse challenge aerosol calibration method.
The company's product line includes the NGI (Next gar Generation Impactor) equipped with Gentle Rocker dissolution tool; the ACI (Andersen Cascade Impactor
) equipped with the Alberta Throat, a more "patient-representative" alternative to the standard induction port; and the FSA (Fast Screening Andersen) and FSI (Fast Screening Impactor) tools for abbreviated impactor measurement.
A two-stage viable cascade impactor
was connected to a pressure/vacuum pump calibrated to 28.3 L/min.