catenin


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catenin

[′kat·ə·nən]
(biochemistry)
Any of a family of 80-102-kilodalton proteins that are thought to have a major role in regulation of cell-to-cell adhesion, which is related to their interaction with E-cadherin and the actin cytoskeleton.
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Immunohistochemically, these tumors show positivity for neuron specific enolase (NSE), vimentin, CD10, progesterone receptor (PR) and [beta] catenin, variable positivity for synaptophysin and cytokeratin and negativity for chromogranin4,8,11,12.
Adhesive and signaling functions of cadherins and catenins in vertebrate development.
Dabbs DJ, Bhargava R, Chivukula M: Lobular versus ductal breast neoplasms: the diagnostic utility of p120 catenin.
Elevated levels of beta catenin are associated with the development of variety of tumours.
The p120 catenin family: complex roles in adhesion, signaling and cancer.
Inhibition of catenin using these LNAs results in the inhibition of spheroid formation in the SW480 -cell line.
The connection between these two cellular components--microtubules and cell-cell junctions--occurs via the interaction between the CLASP2 and pi20 catenin proteins, linked to microtubules and cell junctions respectively.
The [alpha] and [beta] catenins are complexed with the carboxy-terminal cytoplasmic tail of E-cadherin, whereas the p120 catenin is anchored to the E-cadherin in a juxtamembranous site.
Prognostic value of the preserved expression of the E-cadherin and catenin families of adhesion molecules and of [beta]-catenin mutations in synovial sarcoma.
Alpha catenin is silenced in many types of epithelial cancer - skin cancer, colon cancer and other squamous cell cancers," Camargo said.
In such cases, p120 catenin has been suggested as a useful immunomarker for LN.