DNA

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DNA:

see nucleic acidnucleic acid,
any of a group of organic substances found in the chromosomes of living cells and viruses that play a central role in the storage and replication of hereditary information and in the expression of this information through protein synthesis.
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DNA (deoxyribonucleic acid)

See GENETICS.

DNA

(biochemistry)

DNA

deoxyribonucleic acid; a nucleic acid that is the main constituent of the chromosomes of all organisms (except some viruses). The DNA molecule consists of two polynucleotide chains in the form of a double helix, containing phosphate and the sugar deoxyribose and linked by hydrogen bonds between the complementary bases adenine and thymine or cytosine and guanine. DNA is self-replicating, plays a central role in protein synthesis, and is responsible for the transmission of hereditary characteristics from parents to offspring

DNA

(1) See Windows DNA and DNA storage.

(2) (Digital Network Architecture) Introduced in 1978, the DNA was Digital's umbrella term for its enterprise network architecture based on DECnet. See Digital Equipment.
References in periodicals archive ?
Nucleosides suppress cccDNA amplification but do not act on preformed cccDNA.
New insight on hepatitis B virus persistence from the study of intrahepatic viral cccDNA. J Hepatol 2005; 42: 302-8.
'A curative regimen might consist of an HBV antigen inhibitor, an immune activator, a cccDNA inhibitor, and a potent nucleoside analogue," Dr.
Compared with untreated cells, ISG+ medium treated cells showed decreased cccDNA and intracellular HBV-DNA demonstrating the inhibitory effect of ISG+ medium (Figure 2(b)).
We used generalized linear models to analyze the association of HBV DNA and cccDNA copy numbers with tumor stages and clinical features after adjusting for sex, age, smoking, and alcohol consumption.
The stability and long- term persistence of viral cccDNA molecules, together with the long half-life of hepatocytes, imply that HBV infection, once it has occurred, may possibly continue for life.
Dandri, "Control of cccDNA function in hepatitis B virus infection," Journal of Hepatology, vol.
cccDNA was detected in liver tissue of baboon 9732 by using real-time PCR.
Although nucleos(t)ide analogues effectively decrease HBV DNA in serum, cccDNA may not be eliminated in the liver.
Attainment of HBeAg or HBsAg seroconversion with therapy is rarely seen, especially in HIV-infected individuals, given the stability of the cccDNA reservoir within infected hepatocytes.
The studies explore the first two critical steps thought to be necessary for a direct acting antiviral therapy to achieve higher cure rates, including the ability to eliminate residual viremia and the prevention of both new viral replication and new cccDNA generation.
This study highlighted an improvement over results with Arrowhead's first-generation compound ARC-520, which targeted only HBV transcripts derived from cccDNA (Wooddell, 2017).