To sort out the role of such random mutations in cancer risk, the Johns Hopkins scientists charted the number of stem cell divisions
in 31 tissues and compared these rates with the lifetime risks of cancer in the same tissues among Americans.
Loss of the ability to orient cell division
results in severe developmental defects in the embryo and is responsible for a number of diseases in adults including neurological disorders like Huntington's as well as others like polycystic kidney disease.
Identifying the specific problem caused by cholesterol will lead to completely new approaches to therapy for many human diseases, including Alzheimer's disease, atherosclerosis and possibly cancer, all of which show signs of defective cell division
In our search for proteins that are responsible for that sensitivity, we found that SIK2 was required for cell division
and that its inhibition offers a novel approach to improving chemotherapy for ovarian cancer that deserves further study," he added.
Blocking the CDK2 pocket after an abnormal kinase dislodges the p27 elbow might be an effective future strategy for preventing cancerous cell division
in these cells," Kriwacki said.
As its name suggests, the enzyme we have studied is from a group known as kinase enzymes which use a particular chemical - a phosphate - to catalyse the reactions that lead to cell division
A team led by Dr Gary Gorbsky at the Oklahoma Medical Research Foundation (OMRF) was able to interrupt and reverse cell division
by manipulating a key protein.
They found the drug arrested cell division
in a variety of human cancer cells grown in mice, including those notoriously resistant to traditional chemotherapy.
The onset of senescence reactivates these genes, shutting down cell division
The giant multi-nucleate cells of the green alga, Boergesenia forbesii, undergo segregative cell division
upon wounding such that small protoplasts are formed within 2 hours.
The new gel works by temporarily stopping the cell division
in the hair follicles, making them "invisible" to the chemotherapy drugs.
A: When carcinogens or viruses activate a cell's cancer-producing oncogenes, those genes start making proteins, many of which are enzymes that control cell division