These complexes are needed to properly unwind chromosomal DNA during cell division
so that two new sets of chromosomes - one for each daughter cell - can be formed from the original set.
Our study shows, in general, that a change in the number of stem cell divisions
in a tissue type is highly correlated with a change in the incidence of cancer in that same tissue," says Vogelstein.
Most chemotherapy drugs targets and attack cells at a particular phase of the cell division
As its name suggests, the enzyme we have studied is from a group known as kinase enzymes which use a particular chemical - a phosphate - to catalyse the reactions that lead to cell division
They found the drug arrested cell division
in a variety of human cancer cells grown in mice, including those notoriously resistant to traditional chemotherapy.
Drug-induced arrest of cell division
has long been considered only a stop-gap measure, because it was presumed the cells would eventually repair their damage and go on to divide again after treatment," explains Igor Roninson, professor of molecular genetics.
The giant multi-nucleate cells of the green alga, Boergesenia forbesii, undergo segregative cell division
upon wounding such that small protoplasts are formed within 2 hours.
The new gel works by temporarily stopping the cell division
in the hair follicles, making them "invisible" to the chemotherapy drugs.
It was in this way that the German botanist Eduard Adolf Strasburger (1844-1912) was able to observe some of the changes that took place during cell division
A: When carcinogens or viruses activate a cell's cancer-producing oncogenes, those genes start making proteins, many of which are enzymes that control cell division
529-534), reporting on the handicapping conditions associated with the neurological damage referred to above, cite the reduction of cell division
in the embryo, the failure of whatever systems have not already matured in the foetus when the rubella strikes, and the continued inflammation (usually from six to eighteen months postnatally but in some rare cases up to 29 years) with its attendant cell damage.
Presence of PSMA at the poles indicated it might have a role in cell division
and chromosome segregation, and we continued our quest to understand this potential function of PSMA," said Dr.