cell lineage


Also found in: Dictionary, Medical, Wikipedia.

Cell lineage

A type of embryological study in which the history of individual blastomeres (cells formed during division of the zygote) or meristem cells is traced to their ultimate differentiation into tissues and organs.

The question of how the animal genome can be regulated to produce the various cell types found in the larval and adult organism is a central concern in developmental biology. A possible approach to this problem would involve tracing the structural fates of the descendants of each of a population of progenitor cells, and then trying to determine which gene products are required for particular steps in the process of cell differentiation.

Some of the most promising cell lineage studies are conducted on a nematode worm, Caenorhabditis elegans, which is a small (1 mm or 0.04 in. in length), nearly transparent worm that lives in soil. Adults are either males or hermaphrodites; the hermaphrodites contain 959 somatic nuclei. The origin of each somatic cell can be traced back to a single blastomere, and the clonal history of each cell has been determined. A detailed genetic map for the 80,000-kilobase genome has been worked out. See Cleavage (embryology), Fate maps (embryology)

Cell lineage analysis in plants, as in animals, involves tracing the origin of particular cells in the adult body back to their progenitor cells. The adult body of a typical plant consists primarily of leaves, stems, and roots. Cells arise continuously during plant life from specialized dividing cell populations called meristems. A shoot apical meristem produces the leaves and stem, and a root apical meristem produces root tissue. The shoot apical meristem will also produce specialized structures, such as cones, flowers, and thorns. Because plant cells do not move during development, and in many cases the plane of cell division is constant, lines of cells, called cell files, all derive from a single meristem cell at the base of the file.

McGraw-Hill Concise Encyclopedia of Bioscience. © 2002 by The McGraw-Hill Companies, Inc.

cell lineage

[′sel ′lin·yəj]
(embryology)
The developmental history of individual blastomeres from their first cleavage division to their ultimate differentiation into cells of tissues and organs.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
In several ascidians such as Halocynthia roretzi and Ciona intestinalis, cell lineages during embryogenesis have been described in detail (Fig.
Data on molluscan embryogenesis and cell lineage suggest that the trochophore-like stage of molluscs is little more than a ciliated gastrula when it first forms and the juvenile body differentiates from this as development progresses through the veliger stage.
Constitutional symptoms are reported most frequently in patients with SM-AHNMD owing to the proliferation of neoplastic mast cells and the nonmast cell lineage component in specific organ systems, while skin lesions, mediator-related events, and gastrointestinal symptoms are reported much less frequently.
It is also still not clear whether PMCs and these late skeletogenic cells are in the same cell lineage or whether the genes and proteins associated with skeletogenesis are independently expressed in different cell lines.
The cell lineage of vermiform embryos has been fully documented in only two dicyemids, Dicyema acuticephalum and D.
The role for a P2X7 receptor in [GH.sub.4][C.sub.1] cells has not been determined; however, it is well known that this cell lineage (growth hormone-producing cells) mediates local inflammatory responses in the pituitary gland and may modulate the hypothalamic pituitary axis during systemic inflammatory reactions (30).
The cells in the study were differentiated further down the beta cell lineage than the PEC-01 pancreatic progenitor cells being tested in ViaCyte's VC-01 product candidate, which is in a Phase 1/2 clinical trial for treatment of type 1 diabetes.
Using intracellular cell lineage techniques on embryos of the lobate ctenophore Mnemiopsis leidyi, however, we showed that the [m.sub.1] micromeres [ILLUSTRATION FOR FIGURE 1A OMITTED] also contribute to comb plate formation during normal development.
Researchers here converted adult mouse respiratory tract cells called Club cells into large, pure populations of induced progenitor-like (iPL) cells, which retained a residual memory of their parental cell lineage and therefore specifically generated mature Club cells.
The cells in the study were differentiated further down the beta cell lineage man the PEC-01 pancreatic progenitor cells being tested in ViaCyte's VC-01 product candidate, which is in a Phase 1/2 clinical trial for treatment of type 1 diabetes.
The keys to unlock the paths cells to other cell lineage specifications from microRNA-deficient embryonic stem are still unknown, however.