cell lineage

Also found in: Dictionary, Medical, Wikipedia.

Cell lineage

A type of embryological study in which the history of individual blastomeres (cells formed during division of the zygote) or meristem cells is traced to their ultimate differentiation into tissues and organs.

The question of how the animal genome can be regulated to produce the various cell types found in the larval and adult organism is a central concern in developmental biology. A possible approach to this problem would involve tracing the structural fates of the descendants of each of a population of progenitor cells, and then trying to determine which gene products are required for particular steps in the process of cell differentiation.

Some of the most promising cell lineage studies are conducted on a nematode worm, Caenorhabditis elegans, which is a small (1 mm or 0.04 in. in length), nearly transparent worm that lives in soil. Adults are either males or hermaphrodites; the hermaphrodites contain 959 somatic nuclei. The origin of each somatic cell can be traced back to a single blastomere, and the clonal history of each cell has been determined. A detailed genetic map for the 80,000-kilobase genome has been worked out. See Cleavage (embryology), Fate maps (embryology)

Cell lineage analysis in plants, as in animals, involves tracing the origin of particular cells in the adult body back to their progenitor cells. The adult body of a typical plant consists primarily of leaves, stems, and roots. Cells arise continuously during plant life from specialized dividing cell populations called meristems. A shoot apical meristem produces the leaves and stem, and a root apical meristem produces root tissue. The shoot apical meristem will also produce specialized structures, such as cones, flowers, and thorns. Because plant cells do not move during development, and in many cases the plane of cell division is constant, lines of cells, called cell files, all derive from a single meristem cell at the base of the file.

cell lineage

[′sel ′lin·yəj]
The developmental history of individual blastomeres from their first cleavage division to their ultimate differentiation into cells of tissues and organs.
References in periodicals archive ?
rosaceus is associated with changes in cell lineage and germ layer allocation, we studied the cell lineage of C.
6,12 Spencer et al reviewed 40cases where Pan B cell markers (CD20, CD79a) established B cell lineage in 39 cases.
2010) An essential developmental checkpoint for production of the T cell lineage.
Stem cells are any undifferentiated, progenitor cells that are able to self-renew and differentiate into one or more different cell lineages.
plant polysaccharides) utilization; lipid and micronutrient absorption; maintenance of amino acid homeostasis; nitrogen recycling; vitamin synthesis Developmental functions (7,14,15) Postnatal intestinal maturation; morphogenesis and epithelial cell lineage differentiation; angiogenesis Immune system functions (9,16) Influence the development of the gut associated lymphoid tissue (GALT); contribute to both innate and adaptive immune responses
This research might include the use of mutants to understand the mechanisms controlling the following processes: neurogenesis, nervous system patterning, cell lineage, cell migration, formation of neural circuits, programmed cell death, axon pathfinding and regeneration, myelination, and motor and sensory function.
Further immunological characterization of pathological cells in the clinical laboratory should be performed whenever a specific feature of these cells has been shown to be of clinical importance for the diagnosis (immunological features that are specific of a certain cell lineage and maturation stage), prognosis (subclassification of leukemias affecting the same hemopoietic cell lineage according to differentiation features or phenotypic characteristics associated with certain genetic abnormalities), or monitoring of the disease (investigation of phenotypic aberrations and abnormal differentiation pathways).
The cells in the study were differentiated further down the beta cell lineage man the PEC-01 pancreatic progenitor cells being tested in ViaCyte's VC-01 product candidate, which is in a Phase 1/2 clinical trial for treatment of type 1 diabetes.
Cell lineage analysis in ascidian embryos by intracellular injection of a tracer enzyme.
In the study, the researchers found that a certain transcription factor, which are molecules in the cell nucleus that control the activity of cells, continually suppresses the killer T cell lineage in helper T cells.
elegans germline stem cell region, giving immunohistological techniques for study, describing how to use genetic tools to trace cell lineage and gene manipulation, determining the structured polarity of male germline stem cells, conducting high-resolution light microscopic characterization of spermatogonia, identifying and characterizing spermatogonial subtypes, attaining epigenetic control in male germ cells and maintaining spermatogonial germ cells in vivo and in vitro.