CD4+ T cells in cancer stroma, not CD8+ T cells in cancer cell nests
, are associated with favorable prognosis in human non-small cell lung cancers.
Caption: Figure 2: Histopathologic findings: (a) low magnification of skin surface showing intact, thinned epidermis with narrow grenz zone of uninvolved papillary dermis and subjacent epithelial proliferation of basaloid lesional cell nests
arranged in a "jigsaw pattern," H&E stain, 40x; (b) low magnification of deep edge of tumor with basaloid nests pushing into subcutaneous adipose tissue, H&E stain, 40x.
It has also been reported that infiltration of CD1a-positive DC within tumor cell nests
and peritumoral area correlates with decreased tumor thickness and the radial growth phase of melanomas, respectively .
The basal and peritrophic membranes exhibited a moderate reaction to PAS, allowing their identification; whereas the regenerative cell nests
and muscle layers were negative for this histochemical test (Fig.
were separated by thin fibrous bands and, at places, pink hyaline material.
The characteristic cell nests
surrounded by highly vascularized stroma ("zellballen pattern") support the diagnosis of paraganglioma.
Prominent epithelial infiltration by lymphocytes is characteristic (figure, B), as is the presence of epimyoepithelial islands, which are epithelial cell nests
extensively infiltrated by lymphocytes (figure, C).
The defining female characteristics were the formation of protogonial germ tissue into spherical germ cell nests
, separation of a tissue layer from the outer epithelial layer of the lobe-forming ovarian walls, a tissue bud growing from the suspensory tissue that helped form the ovary wall, and the proliferation of oogonia and oocytes.
Histology showed that this lesion had deep penetrating tumor cell nests
that obliterated the normal structure of the sebaceous gland.
(14) The stroma surrounding cell nests
is comprised of spindled cells with long tapered cytoplasmic processes, tapered nuclei, bland nuclear chromatin, and a small pinpoint nucleolus typical of myofibroblasts.
Microscopically, tumorous tissue revealed proliferating squamous cell which were characterized by presence of epithelial pearls and cell nests
. Electron microscopic examination of tumorous tissue revealed pleomorphic epithelial cells with enlarged nuclei.
of cases Incidence % 1 Normal 585 69.67 2 Abnormal 255 30.33 1 Salpingitis 124 14.76 Acute 32 3.81 Chronic 83 9.87 Tuberculosis 5 0.59 Suture granuloma 4 0.48 2 Hydrosalpinx 56 6.65 3 Salpingtis Isthmica Nodosa 4 0.48 4 Ectopic pregnancy 58 6.90 5 Endometriosis 3 0.36 6 Paratubal cysts 6 0.71 7 Walthard cell nests
2 0.24 8 Actinomycosis 1 0.12 9 Primary Tubal Adenocarcinoma 1 0.12 AGE WISE DISTRIBUTION OF TUBAL LESIONS: