cell permeability

Cell permeability

The permitting or activating of the passage of substances into, out of, or through cells, or from one cell to another. These materials traverse either the cell surface that demarcates the living cytoplasm from the extracellular space or the boundaries between adjacent cells. In many cases the materials also traverse the cell wall. See Cell walls (plant)

The cell can control many properties of its membranes, including those related to permeability. Control can be exerted in the following ways: (1) by varying the number and variety of membranes; (2) by varying the specific nature of the lipid components in the membrane; (3) by varying the glycocalyx proteins or lipid-associated sugar molecules on the outside of the cell, or the membrane-associated proteins on the inside; (4) by causing large areas of membrane to flow from one place to another, or to fold, indent, evert, or pinch off, carrying with these movements substances bound to one or the other surface of the membrane, or embedded in it; (5) by selectively moving integral membrane proteins in the plane of the membrane, allowing these proteins to carry with them substances, particles, molecules, or other materials bound to them; (6) by varying the properties of a single integral membrane protein or of a closely associated group of them so as to allow or prevent the passage across the membrane of substances such as ions or proteins of a specific character. See Cell membranes

cell permeability

[′sel pər·mē·ə′bil·əd·ē]
(cell and molecular biology)
The permitting or activating of the passage of substances into, out of, or through cells.
References in periodicals archive ?
We hypothesized that during hypoxia, an increase in the HIF-1[alpha] and VEGF protein expression would lead to an increase in bladder cancer cell permeability, and that HIF-1[alpha] is an important factor in the increase of bladder cancer cell permeability.
The main vascular endothelial cell permeability modulation is contraction caused by the interaction of actin and myosin.
Finally, from in vitro experiments it is known that IL-17A increases endothelial cell permeability at 10 or 100ng/mL doses [78, 79].
Therapeutic ultrasound increases cell permeability by setting up the cavitations, thus aiding in cell communication across articular membrane and linings.
The nano-mist results in outstanding cell permeability that increases the moisture content of the skin, enhancing its moisture retention property.
The collaboration, established in December 2009, utilized Trartzyme's chemistry technology, Macrocyclic Template Chemistry (MATCH), for the discovery of novel active macrocycles against a range of biological targets with high potency and selectivity, as well as high oral availability, good tissue and cell permeability.
High content screening (HCS) was used to observe the nuclear condensation, cell permeability, mitochondrial membrane potential (MMP) and cytochrorne c release.
The effects of AWT on tissue include the stimulation of microcirculation and improvement in cell permeability.
As noted by the authors, alterations in Clara cell permeability are thought to play a role in the development of asthma, which has been linked to indoor swimming pool exposure.
Specific topics include cadherins and connexins in pulmonary endothelial function, pulmonary endothelial progenitor cells, oxidant-mediated signaling and injury in pulmonary endothelium, therapeutic strategies to limit pulmonary endothelial cell permeability, genetic insights into endothelial barrier regulation in the acutely inflamed lung, and collagen vascular diseases and pulmonary endothelium.
This finding was not thought to be a result of decreased cell permeability to the enzyme because other enzymes of cytoplasmic origin were not decreased in serum.
The variation of these subunits can be used to subtly modulate activity, selectivity and ADMET properties such as cell permeability and oral bioavailability.