cell-mediated immunity


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cell-mediated immunity

[¦sel ¦mē·dē‚ād·əd i′myü·nəd·ē]
(immunology)
Immune responses produced by the activities of T cells rather than by immunoglobulins.
References in periodicals archive ?
Optimistic expectancies and cell-mediated immunity: the role of positive affect.
Mascolini: The Merck vaccine that failed in the STEP trial tried to stimulate cell-mediated immunity. Can a vaccine that stimulates only T-cell-based immunity have a significant impact on the HIV epidemic?
The vaccines of the present invention provide effective immunoprophylaxis against papillomavirus infection through neutralizing antibody and cell-mediated immunity. (US 7,482,428)
The UCLA study was significant as it was the first to demonstrate that a behavioral intervention like tai chi can positively influence a virus-specific cell-mediated immunity response.
When antigens intrude into the body, the spleen notifies T and B cells, thus stimulating cell-mediated immunity and humoral immunity (Ezekowitz and Hoffman, 1998).
In case 1, the corticotherapy may have accelerated the healing of the ulcers and limited the fibrinoid necrosis, avoiding the deleterious effects of exacerbated host cell-mediated immunity [5].
* It has been hypothesized that HIV associated disregulation of cortisol may play a role in the pathophysiology of AIDS, including modulation of cell-mediated immunity. Experimental evidence suggests that cortisol and its receptors are critically involved at some level in the regulation of immune function in HIV infection.
A decrease in cell-mediated immunity is thought to contribute to the immunosuppression seen in adults, but the mechanisms for this are not completely understood.
Cell-mediated immunity is used when intracellular pathogens or abnormal body cells are present because antibodies are unable to enter cells.
Two measures of response were used in this paper: stimulation index, a measure of so-called 'cell-mediated immunity' (CD4 responses), and [gamma]-interferon enzyme-linked immunosorbent spot (ELISPOT), which demonstrates the presence and frequency of [gamma]-interferon-secreting cells, a marker for the presence of cytotoxic T-cells (CD8 cells).

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