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see thyroid glandthyroid gland,
endocrine gland, situated in the neck, that secretes hormones necessary for growth and proper metabolism. It consists of two lobes connected by a narrow segment called the isthmus. The lobes lie on either side of the trachea, the isthmus in front of it.
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The Columbia Electronic Encyclopedia™ Copyright © 2013, Columbia University Press. Licensed from Columbia University Press. All rights reserved. www.cc.columbia.edu/cu/cup/
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



decreased functioning of the thyroid gland. Hypothyroidism is a mild form of myxedema. Its basic symptoms are fatigue, slowing down of physical and mental activity, somnolence, sluggishness, decreased memory, sensitivity to cold, puffiness of the face, edematous eyelids, dryness of skin, loss of hair, constipation, and lowered basal metabolism. The treatment for hypothyroidism is hormone therapy.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.


Condition caused by deficient secretion of the thyroid hormone.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Is the thyrotropin-releasing hormone test necessary in the diagnosis of central hypothyroidism in children.
Clinical review: Central hypothyroidism: pathogenic, diagnostic, and therapeutic challenges.
Neonatal screening and a new causeof congenital central hypothyroidism. Ann Pediatr Endocrinol Metab 2014;19:117-121.
Mutations in TBL1X Are Associated With Central Hypothyroidism. J Clin Endocrinol Metab 2016;101:4564-4573.
Thyrotropin suppression by thyroid hormone replacement is correlated with thyroxine level normalization in central hypothyroidism. Thyroid 2002;9:823-827.
In the present case, IGSF1 deficiency was diagnosed at the age of 19 years, based on a history of transient GH deficiency, persistent central hypothyroidism, and hypoprolactinemia, and the finding of macro-orchidism.
Because of the combination of central hypothyroidism, GH deficiency, low PRL status, and normal pituitary imaging, genetic testing of PROP1 and POU1F1 was performed, but no mutations were found.
The combination of persistent central hypothyroidism, transient partial GH deficiency, and macro-orchidism led to the suspicion of IGSF1 deficiency (1).
The diagnosis of central hypothyroidism is rarely made at birth as most neonatal screening programs for congenital hypothyroidism are based solely on the measurement of TSH.
Up to now, systematic IGSF1 mutation analysis has not been performed in larger cohorts of patients with transient or persistent GH deficiency in combination with central hypothyroidism and low PRL levels.
Male children with an idiopathic combined GH and TSH deficiency, showing a persistent central hypothyroidism but a transient GH deficiency, should be screened for loss-of-function mutations or deletions of the IGSF1 gene, especially when delayed puberty and macro-orchidism are present.
Loss-of-function mutations in IGSF1 cause an X-linked syndrome of central hypothyroidism and testicular enlargement.

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