methanol n = 31, T2 n = (1987a, b) extract of Tw 27) Skin rash and cheilosis
(1, 15) Diarrhoea (0, 6) Anorexia (0, 2) Abdominal pain (1, 2) Amenorrhoea (0, 5) Postmenopausal vaginal bleeding (0, 1) Total (2, 31) (4 weeks after Adverse events in 4 weeks crossover: after crossover (placebo, placebo n = 24, T2) T2 n = 25) Skin rash and cheilosis
(0, 7) Diarrhoea (0, 2) Anorexia (1, 0) Amenorrhoea (5, 1) Withdrawals due to AEs: four from T2 treatment in first 12 weeks including one case of feverishness and aplastic anaemia after mistaken medication with 180 mg/day of T2 for 2 weeks and one case of anorexia and death through heart failure.
During physical examination it is important to pay attention to clues such as skin pallor, cheilosis
, bleeding gums, hair and muscle condition, or change in vision.
In addition to NME and diabetes mellitus, the most common presenting symptoms are weight loss, cheilosis
, stomatitis, diarrhea, weakness, and mental changes.