chelation


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Related to chelation: EDTA

chelation

[kē′lā·shən]
(organic chemistry)
A chemical process involving formation of a heterocyclic ring compound which contains at least one metal cation or hydrogen ion in the ring.
References in periodicals archive ?
Some proponents of chelation therapy say that it can improve blood flow in the arteries by removing the calcium from plaque that has built up on the artery walls.
Hence from this data we cannot conclude that DMSA or EDTA are suitable for barium chelation. More studies and evaluations are needed.
(2) Chelation therapy with calcium ethylenediaminetetraacetate (CaEDTA) was started (35 mg/kg IM q12h for 5 days; CaEDTA, Diamondback Drugs, Scottsdale, AZ, USA).
He requires iron chelation therapy to reduce the iron load in the body, lifelong.
No other significant correlation was found between oral chelation, amount and duration of blood transfusion, or serum ferritin levels.
In the medical literature, at least 30 deaths have been attributed to it, including that of five-year-old Abubakar Tariq Nadama, from Plymouth, who died of a heart attack while undergoing chelation.
Chelation, on the other hand, uses EDTA (ethylene diamine tetra acetic acid) made of amino acids that are the building blocks of proteins, to leach out metabolically active calcium embedded in the arterial walls.
Laboratory data On day 1 of On day 19 after Normal range admission chelation therapy Hemoglobin 9.4g/dL 11.5 g/dL 13.5-17.5 Hematocrit 27.9% 42% 41-53% AST 57 U/L 32 U/L 0-37 U/L ALT 87U/L 40 U/L 0-40 U/L Blood lead level 62.8 g/dL 31 g/dL <40 [micro]g/dL Urine delta-ALA 81.8 mg/L nil <7mg/L/24hr Urine PBG 1.0 mg/L nil <4mg/L/24hr ALT = alanine aminotransferase; AST = aspartate aminotransferase; PBG = porphobilinogen; ALA = aminolevulinic acid.
Treatment of patients with b-thalassemia major includes long term blood transfusions, iron chelation, splenectomy and bone marrow transplantation.
As per published protocol, Chelation therapy dose adjustment is based on kidney function and other parameters and is administered intravenously once or twice weekly for 20-30 treatments.
Age, sex, height, weight, mean pre-transfusion Hb over past 2 years' duration and volume of blood transfusion, age at the start of chelation therapy, duration of chelation, serum ferritin in last 6 months, HBsAg and family history of diabetes were noted.
Evaluation of the Trial to Assess Chelation Therapy (TACT): The Scientific Process, Peer Review, and Editorial Scrutiny.