chelerythrine


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chelerythrine

[‚kel·ə′rī‚thrēn]
(organic chemistry)
C21H17O4H A poisonous, crystalline alkaloid, slightly soluble in alcohol; it is derived from the seeds of the herb celandine (Chelidonium majus) and has narcotic properties.
References in periodicals archive ?
We therefore tested the effect of the PKC inhibitor chelerythrine on BM-DC-derived ROS formation and maturation.
Differential effect of sanguinarine, chelerythrine and chelidonine on DNA damage and cell viability in primary mouse spleen cells and mouse leukemic cells.
bungeanum leaves; (2) to measure the antioxidant and antimicrobial activities of the different polarity fractions; (3) to quantify the content of twelve natural compounds (chlorogenic acid, epicatechin, rutin, hyperoside, trifolin, quercitrin, kaempferol-3-rhamnoside, quercetin, nitidine chloride, chelerythrine, xanthyletin, and sesamin) in the different polarity fractions by RP-HPLC analysis; and (4) to compare the similarities and differences of the phytochemical composition in the different polarity fractions.
Inhibitors of protein kinase C (PKC; chelerythrine chloride), glycogen synthase kinase3 (GSK3; SB216763), [Ca.sub.2+]/calmodulin-dependent protein kinase II (CaMKII; KN62), and protease as well as phosphatase inhibitor cocktails were supplied by Calbiochem (San Diego, CA, USA).
In a similar fashion, isoflurane-mediated mPTP closure was abolished when rats were pre-exposed to the non-selective protein kinase C (PKC) inhibitor chelerythrine and the selective PKC [epsilon]-isoform inhibitor [epsilon]V1-2, but not when pre-exposed to the selective PKC S-isoform inhibitor, rottlerin (22).
PKC inhibitor chelerythrine chloride ([C.sub.21][H.sub.18]N[O.sub.4]Cl) was obtained from Calbiochem (Bad Soden, Germany), and p42/44 MAPK inhibitor U0126 was purchased from Promega (Madison, WI, USA).
Isoquinoline alkaloids such as coptisine, allocryptopine, protopine, berberine, chelidonine, sanguinarine, and chelerythrine are the main constituents of Chelidonium majus L.
Chelerythrine Chloride and Its Effects on Behavioral and Physiological Responses in Female Crickets (Acheta domesticus).
Damjanovich et al., "Apoptotic response of uveal melanoma cells upon treatment with chelidonine, sanguinarine and chelerythrine," Cancer Letters, vol.