Design strategies, results and evaluations of long-term chemical carcinogenesis
KEGG annotation unveiled that there were 30 upregulated pathways (including chemical carcinogenesis
, drug metabolism, and p53 signaling pathway) and 37 downregulated pathways (including DNA replication, cell cycle, and Fanconi anemia pathway).
Dietary supplementation of curcumin enhances antioxidant and phase II metabolizing enzymes in ddY male mice: possible role in protection against chemical carcinogenesis
Tobacco Smoke: Chemical Carcinogenesis
and Genetic Lesions.
One important development was the proposal of the theory chemical carcinogenesis
in three stages: initiation promotion and latency.
Skin-Specific Deletion of Stat3 Reveals Roles in both the Initiation and Promotion Stages of Two-Stage Chemical Carcinogenesis
Consequently, GST-P1 expression has been considered as a diagnostic indicator of chemical carcinogenesis
(Tidefelt et al., 1992; Grignon et al., 1994; Hamada et al., 1994).
Illinois, Chicago that stated, "Resveratrol can inhibit all three stages of chemical carcinogenesis
-- tumor initiation, promotion, and progression" (quoted from the Lancet).
"We know these compounds can probably cause cancer in humans," says Elizabeth Snyderwine, Chief of the Chemical Carcinogenesis
Section at the National Cancer Institute (NCI) in Bethesda, Maryland.
The next four chapters review the fundamentals of toxicology, including the dose-response relationship, metabolism of xenobiotics, toxicity testing, variations in individual responses and chemical carcinogenesis
. These chapters give a succinct overview of toxicology, particularly from a biochemical perspective without going into a great detail on the underlying biology.
In another paper, chemist Chung, associate chief of the American Health Foundation's division of Chemical Carcinogenesis
, reported there is also evidence that green tea can reduce the incidence of smoking-related lung cancer.
* TOXLINE, a subfile of the National Library of Medicine database covering the toxicological, pharmacological, biochemical, and physiological effects of drugs and other chemicals in such areas as drug reactions, air pollution, chemical carcinogenesis
, food contamination, water treatment and more.