chemokine


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Related to chemokine: cytokine, interleukin, Chemokine receptor

chemokine

[′kē·mə‚kīn]
(cell and molecular biology)
A small (7-14 kilodaltons of soluble protein) chemoattractant cytokine produced by cells and tissues at the beginning of an immune system response to infection, allergen, injury, and so forth that controls the nature and magnitude of immune cell infiltration and inflammation at the affected site.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
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- The report reviews C-X-C Chemokine Receptor Type 2 (CDw128b or GRO/MGSA Receptor or High Affinity Interleukin 8 Receptor B or IL8 Receptor Type 2 or CD182 or CXCR2) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources
CCL, CC-motif chemokine ligand; CXCL, CXC-motif chemokine ligand; G-CSF, granulocyte colony-stimulating factor; IFN-y, interferon y; IL, interleukin; MMP, matrix metalloproteinase; sICAM-1, soluble intercellular adhesion molecule 1; VEGF-A, vascular endothelial growth factor A.
WHIM syndrome is a primary immunodeficiency disorder characterized by panleukopenia and caused by autosomal dominant gain-of-function mutations in CXC chemokine receptor 4 (CXCR4).
The CC-type ligands CCL17, CCL21, and CCL24 are considered dual chemokine and homeostatic chemokines, respectively.
While our study focused on eotaxin-2, this chemokine acts in close interaction with a large number of additional mediators, which has not been investigated in the present cohort.
Nonparametric Kruskal-Wallis followed by Mann-Whitney U tests, when appropriate, were performed to determine the statistical significance for the difference of cytokine and chemokine concentrations between the BMS-COPD, BMS-CONTROL, and TS-BMS-CONTROL or TS-COPD, TS-CONTROL, and TS-BMS-CONTROL groups.
The recruitment of activated lymphocytes to mucosal surfaces is strictly controlled, requiring the expression of specific chemokine receptors and adhesion molecules.
KEYWORDS: Atypical chemokine receptor 1, Hepatitis C virus, Liver damage, Liver fibrosis, Polymorphism, Serum liver related markers.
Inhibition of phosphodiesterase 4 suppresses lipopolysaccharide-induced CC chemokine ligand 3 production in mouse macrophages
Although the molecular mechanisms regulating HIV chemokine receptors in the cervix are unclear, inflammatory prostaglandins derived by metabolism of arachidonic acid by cyclo-oxygenase enzymes (COX-1 and COX-2)[9] have been shown to regulate HIV chemokine expression in uterine epithelial cells in the female genital tract.
The papers range from 'Microbial Sensing by Toll-Like Receptors and Intracellular Nucleic Acid Sensors; to The Chemokine System in Innate Immunity; to Inflammation and the Blood Microvascular System; to Approaching the Next Revolution?

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