chemokine


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Related to chemokine: cytokine, interleukin, Chemokine receptor

chemokine

[′kē·mə‚kīn]
(cell and molecular biology)
A small (7-14 kilodaltons of soluble protein) chemoattractant cytokine produced by cells and tissues at the beginning of an immune system response to infection, allergen, injury, and so forth that controls the nature and magnitude of immune cell infiltration and inflammation at the affected site.
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KEYWORDS: Atypical chemokine receptor 1, Hepatitis C virus, Liver damage, Liver fibrosis, Polymorphism, Serum liver related markers.
Aims: To determine the association of an atypical chemokine receptor 1 polymorphism (rs12075) with hepatitis C virus susceptibility.
The report provides comprehensive information on the C-C Chemokine Receptor Type 5 (C-C CKR-5 or CHEMR13 or HIV-1 Fusion Coreceptor or CD195 or CCR5), targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type.
Gq is the most commonly studied subclass of the Gq/11 subfamily in the field of immunology [18] and is mainly coupled to sex hormone receptors and some chemokine receptors, which are differentially expressed in certain types of lymphocytes [6,18] (Table 1).
8) However, the way that this viral encoded chemokine interacting with PBMC and the detailed mechanism involved in virus entry into host cells needs further study.
We found that in addition to TNF-a, the proinflammatory chemokine CC chemokine ligand 3 (CCL3) also was downregulated by rolipram whereas the anti-inflammatory cytokine interleukin-1 receptor antagonist (IL-1Ra) was upregulated.
Our data indicate that JYGCT attenuates TNF-[alpha] and IFN-[gamma]-mediated chemokine production by targeting the STAT1 and NF-[kappa]B signalling in keratinocytes.
One of the most commonly studied chemokine receptors is CCR5--a G protein coupled receptor inhibiting cAMP production, stimulating of Ca2+ ion release, and being the activator of MAP and Jun-N-terminal kinases [6].
Human macrophage-derived chemokine (MDC), a novel chemoattractant for monocytes, monocyte-derived dendritic cells, and natural killer cells.
According to the company, bertilimumab (iCo-008 or CAT-213) is a human immunoglobulin monoclonal antibody targeting eotaxin-1, a member of the chemokine family of proteins that act as messenger molecules between the cells of the immune system.
Ransohoff considers himself lucky to have "tripped over" this discovery, which introduced him to the relatively new field of chemokine study.
The "Global Laboratory Chemical Reagents Industry" report analyzes the worldwide markets for Laboratory Chemical Reagents by the following Product Segments: Molecular Biology (Monoclonal & Polyclonal Antibodies, Gene Expression, Vectors, Cloning, & Sequencing, Gene Synthesis, Extraction Kits, PCR Reagents, Enzymes, & Others), Biochemistry (IVD), Cytokine & Chemokine Testing, Cell/ Tissue Culture, Carbohydrate Analysis, Immunohistochemistry, and Environmental Testing (Pesticide Residues, & Others).

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