- The report reviews C-X-C Chemokine
Receptor Type 2 (CDw128b or GRO/MGSA Receptor or High Affinity Interleukin 8 Receptor B or IL8 Receptor Type 2 or CD182 or CXCR2) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources
CCL, CC-motif chemokine
ligand; CXCL, CXC-motif chemokine
ligand; G-CSF, granulocyte colony-stimulating factor; IFN-y, interferon y; IL, interleukin; MMP, matrix metalloproteinase; sICAM-1, soluble intercellular adhesion molecule 1; VEGF-A, vascular endothelial growth factor A.
WHIM syndrome is a primary immunodeficiency disorder characterized by panleukopenia and caused by autosomal dominant gain-of-function mutations in CXC chemokine
receptor 4 (CXCR4).
The CC-type ligands CCL17, CCL21, and CCL24 are considered dual chemokine
and homeostatic chemokines
While our study focused on eotaxin-2, this chemokine
acts in close interaction with a large number of additional mediators, which has not been investigated in the present cohort.
Nonparametric Kruskal-Wallis followed by Mann-Whitney U tests, when appropriate, were performed to determine the statistical significance for the difference of cytokine and chemokine
concentrations between the BMS-COPD, BMS-CONTROL, and TS-BMS-CONTROL or TS-COPD, TS-CONTROL, and TS-BMS-CONTROL groups.
The recruitment of activated lymphocytes to mucosal surfaces is strictly controlled, requiring the expression of specific chemokine
receptors and adhesion molecules.
KEYWORDS: Atypical chemokine
receptor 1, Hepatitis C virus, Liver damage, Liver fibrosis, Polymorphism, Serum liver related markers.
Inhibition of phosphodiesterase 4 suppresses lipopolysaccharide-induced CC chemokine
ligand 3 production in mouse macrophages
Although the molecular mechanisms regulating HIV chemokine
receptors in the cervix are unclear, inflammatory prostaglandins derived by metabolism of arachidonic acid by cyclo-oxygenase enzymes (COX-1 and COX-2) have been shown to regulate HIV chemokine
expression in uterine epithelial cells in the female genital tract.
The papers range from 'Microbial Sensing by Toll-Like Receptors and Intracellular Nucleic Acid Sensors; to The Chemokine
System in Innate Immunity; to Inflammation and the Blood Microvascular System; to Approaching the Next Revolution?