This protection with relatively short use and its fairly stable magnitude thereafter bode well for using bisphosphonates for chemoprevention
, according to Dr.
Advanced adenomas--large, intramucosal or invasive adenomas containing histologic features associated with conversion to colorectal cancer--were seen in nine (9.3%) patients in the placebo group and one patient receiving combination chemoprevention
. More than one adenoma was found in 15 patients receiving placebo versus just 1 patient in the chemoprevention
This finding is particularly relevant because multiple large, long-term, multicenter phase III clinical trials of aromatase inhibitors for breast cancer chemoprevention
are getting underway this year.
A number of agents are being investigated for the chemoprevention
of skin cancers.
Since the start of the randomized Aspirin Esomeprazole Chemoprevention
Trial (AspECT) in September 2005, 1,192 (83%) of the 1,436 patients have remained on their medication, and just 33 adverse events have been reported, said the study's lead investigator Dr.
He and his colleagues plan to launch a prospective prostate cancer prevention trial using risk alleles and family history to guide chemoprevention
; v.2: Strategies for cancer chemoprevention
Preventive Services Task Force "strongly" recommended last month that "clinicians discuss aspirin chemoprevention
with adults who are at increased risk of coronary heart disease."
Induction of phase II genes may contribute to primary chemoprevention
of colon cancer by apple polyphenols.
Digoxin could conceivably find a role for chemoprevention
in selected high-risk men, or perhaps in the treatment of prostate cancer, but its potent cardiovascular effects make it poorly suited for use in broad-scale chemoprevention
, she said.
Perhaps one man's binge drinking is another man's chemoprevention
. The micronutrient xanthohumol, a flavonoid compound found only in hops, shows promise in cancer prevention, according to a report from the Linus Pauling Institute at Oregon State University in Corvallis.
white women aged 35-49 years who have any risk factors for breast cancer would derive substantial net benefit from 5 years of tamoxifen for chemoprevention