Using licensed technology developed by GreenCentre Canada, the catalyst combines high activity with high chemoselectivity
that could revolutionise industrial applications of ester hydrogenation.
In order to achieve high chemoselectivity
in a subsequent chemical reaction, it is necessary to use protecting groups.
The first chapter discusses the modes of selectivity: chemoselectivity
, regioselectivity, stereoselectivity, and enantioselectivity, with examples and comments on synthetic strategy.
This observation led us further to the study on chemoselectivity
aspects from reduction process.
They also exhibit good chemoselectivity
, regioselectivity and enantioselectivity, and as hydrolases they do not require cofactors.
The first part of this research focuses on H-bonding effects on the chemoselectivity
of the esterification reaction.
25 ppm are the characteristic peaks, which is the basis of our study to follow the chemoselectivity
of addition reaction.
Depending on the metal used, they show different chemoselectivity
in mediating the coupling between allyl halides and carbonyl compounds: In and Sn allylate both aldehydes and ketones; Bi allylates aldehydes and selected ketones; Sb allyates only aldehydes and Mn only aryl aldehydes.
The use of bioorthogonal chemical reactions for labelling and probing specific biomolecules is an exciting option but a very challenging task as these transformations should proceed very rapidly in physiological conditions with complete chemoselectivity
The aim of this project is to develop new ligation processes with high efficiency, large scope of application, high chemoselectivity
and high rates.
Importantly, some special features such as regioor chemoselectivity
could be obtained using PIL catalysts [23-29].
Recently, Pd and InCl3 in presence of aldoxime exhibited excellent chemoselectivity
for the hydration of nitrile groups [12 -13].