The aim of this project is to develop new ligation processes with high efficiency, large scope of application, high chemoselectivity
and high rates.
They also exhibit good chemoselectivity
, regioselectivity and enantioselectivity, and as hydrolases they do not require cofactors.
The first part of this research focuses on H-bonding effects on the chemoselectivity of the esterification reaction.
The chemoselectivity of the esterification reaction was attributed to the H-bond withdrawing electrons from the carbonyl, thereby promoting the nucleophilic attack by an OH group.
25 ppm are the characteristic peaks, which is the basis of our study to follow the chemoselectivity
of addition reaction.
Depending on the metal used, they show different chemoselectivity
in mediating the coupling between allyl halides and carbonyl compounds: In and Sn allylate both aldehydes and ketones; Bi allylates aldehydes and selected ketones; Sb allyates only aldehydes and Mn only aryl aldehydes.
Exploiting Enzyme Chemoselectivity
and Regioselectivity (Sergio Riva).