Compounds 3[alpha]-[[sup.18]F]fluorocholic acid (3[alpha]-[[sup.18]F]FCA), 3[beta]-[[sup.18]F]fluorochenodeoxycholic acid (3[beta]-[[sup.18]F]FCDCA), and 3[beta]-[[sup.18]F]fluoroglycocholic acid (3[beta]-[[sup.18]F]FGCA) on the upper row differ in bile acid structure (cholic acid, chenodeoxycholic acid
, and glycocholic acid) or 3 [alpha]/[beta] position of the radiolabel.
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Abbreviations: CA, cholic acid; CDCA, chenodeoxycholic acid
; DCA, deoxycholic acid; G, glycine-conjugated; LCA, lithocholic acid; MCA, muricholic acid; NS, not significant; T, taurine-conjugated species; UDCA, ursodeoxycholic acid.
3[beta]-Hydroxy-[[DELTA].sup.5]-C27-steroid dehydrogenase deficiency; effect of chenodeoxycholic acid
therapy on liver histology.
Cerebrotendinous xanthomatosis treatment includes chenodeoxycholic acid
and HMG-CoA-reductase inhibitors.
Solutions of chenodeoxycholic acid
(4 x [10.sup.-2] M) were prepared in ethanol and in ethanol with 10% DMSO and used after dilution from 5 to 20 mM.
The acid, CDCA (chenodeoxycholic acid
) is one of the major bile acids that are produced in the liver, then secreted--via the gall bladder and bile duct--into the upper digestive tract to help the body digest fat.
Bile acids are the major constituent of bile and the primary bile acids, cholic and chenodeoxycholic acid
, and secondary bile acids, lithocholic and deoxycholic acid, make up more than 95% of the bile acid pool.
Like UDCA, chenodeoxycholic acid
(CDCA) is a type of bile acid synthesized by the liver and found in small amounts in human bile.
In sodium independent pathway of hepatic uptake of bile salts, major transporter protein is organic anion transporter protein1B1 (OATP1B1) (especially for chenodeoxycholic acid
Bile principally consists of two bile salts, taurocholic acid and chenodeoxycholic acid
, as well as bilirubin.