chloral hydrate


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chloral hydrate

(klōr`əl hī`drāt), central nervous system depressantdepressant,
any one of various substances that diminish functional activity, usually by depressing the nervous system. Barbiturates, sedatives, alcohol, and meprobamate are all depressants. Depressants have various modes of action and effects.
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 that is widely used as a hypnotic, or sleep-inducing drug. Chloral hydrate is the common ingredient, along with alcohol, in what are popularly known as knockout drops or Mickey Finns; the combination can induce acute intoxication and coma.

Chloral Hydrate

 

also known as 2,2,2-trichloroeth-anediol-1,1, CCl3CH(OH)2; colorless crystals that are soluble in water, alcohol, and ether and have a melting point of 53°C. Chloral hydrate is obtained by the interaction of chloral and water. It is a medicinal preparation belonging to the hypnotic group of drugs. It also exhibits sedative, analgesic, and antispasmodic effects. It is taken orally in powder or tablet form or rectally, mainly by persons with sleeping problems or person suffering from anxiety or epilepsy. It is a constituent of Denta tooth drops.

chloral hydrate

[′klȯr·əl ′hī‚drāt]
(organic chemistry)
CCl3CH(OH)2 Colorless, deliquescent needles with slightly bitter caustic taste, soluble in water; a hypnotic. Also known as crystalline chloral; hydrated chloral.

chloral hydrate

a colourless crystalline soluble solid produced by the reaction of chloral with water and used as a sedative and hypnotic; 2,2,2-trichloro-1,1-ethanediol. Formula: CCl3CH(OH)2
References in periodicals archive ?
Paraldehyde and chloral hydrate are still around but have been replaced by the other drugs that do not have such noxious side effects.
According to the complaint before the state dental board, on March 15 an unlicensed dental assistant working for Ford gave 15-year-old Melissa Marie McGrath chloral hydrate at her and her mother's request before a tooth extraction.
Chloral hydrate and benzodiazepines are the drugs of choice in the treatment of sleep disorders associated with stress or environmental changes.
Four other alleged victims, all between 3 and 5 years old, were also given overdoses of chloral hydrate but were less severely affected, MacKenzie said.
Under 10% chloral hydrate anesthesia, rats were irradiated in brain hemisphere (right side: n = 6; left side: n = 6) with a highly collimated 6 MV photon beam from a linear accelerator (Primus-M, Siemens, Germany) with a single dose of approximately 30 Gy.
A detectable decrease in the pH value leads to change the color, the extent of decreasing the pH value depends on the chloral hydrate concentration.
Commonly used anaesthetics were give to the patients who experienced the adverse events, including lidocaine, midazolam, ketamine, propofol, fentanyl and chloral hydrate.
The records contain little information on physical treatment except for the use of such general sedatives as potassium bromide or chloral hydrate.
The medications mentioned prominently in 1976 included among others, Flurazepam, triazolam, chloral hydrate, amylobarbitone, methaqualone, glutethimide, pentobarbital, methyprylone, secobarbital, tryptophan, meprobamate, and the old standby, diphenhydramine.
Initially propofol ketamine and chloral hydrate were evaluated individually as sole anesthetic drugs in groups A C and E respectively.
Oral promethazine, trimeperazine, midazolam, ketamine, chloral hydrate and other various drugs has been used with different success rates.
Menthol crystals, magnesium salts, chloral hydrate, tricaine methanesulfonate (MS-222), alcohol or formalin (drip) and even relaxation by freezing are documented narcotization methods for sea anemones.